Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 04001 Kosice, Slovakia.
Faculty of Physics, Adam Mickiewicz University, Uniwersytetu Poznańskiego 2, 61-614 Poznań, Poland.
Molecules. 2022 Aug 31;27(17):5605. doi: 10.3390/molecules27175605.
A number of materials are studied in the field of magnetic hyperthermia. In general, the most promising ones appear to be iron oxide particle nanosystems. This is also indicated in some clinical trial studies where iron-based oxides were used. On the other hand, the type of material itself provides a number of variations on how to tune hyperthermia indicators. In this paper, magnetite nanoparticles in various forms were analyzed. The nanoparticles differed in the core size as well as in the form of their arrangement. The arrangement was determined by the nature of the surfactant. The individual particles were covered chemically by dextran; in the case of chain-like particles, they were encapsulated naturally in a lipid bilayer. It was shown that in the case of chain-like nanoparticles, except for relaxation, a contribution from magnetic hysteresis to the heating process also appears. The influence of the chosen methodology of magnetic field generation was also analyzed. In addition, the influence of the chosen methodology of magnetic field generation was analyzed. The application of a rotating magnetic field was shown to be more efficient in generating heat than the application of an alternating magnetic field. However, the degree of efficiency depended on the arrangement of the magnetite nanoparticles. The difference in the efficiency of the rotating magnetic field versus the alternating magnetic field was much more pronounced for individual nanoparticles (in the form of a magnetic fluid) than for systems containing chain nanoparticles (magnetosomes and a mix of magnetic fluid with magnetosomes in a ratio 1:1).
在磁热疗领域研究了许多材料。一般来说，最有前途的似乎是氧化铁粒子纳米系统。一些临床试验研究也表明了这一点，其中使用了基于铁的氧化物。另一方面，材料本身的类型为如何调整热疗指标提供了多种变化。本文分析了各种形式的磁铁矿纳米粒子。这些纳米粒子在核心尺寸以及排列形式上有所不同。排列方式由表面活性剂的性质决定。各个粒子通过葡聚糖进行化学覆盖；对于链状粒子，它们在脂质双层中自然被包裹。结果表明，在链状纳米粒子的情况下，除了弛豫之外，磁滞对加热过程也有贡献。还分析了所选磁场产生方法的影响。此外，还分析了所选磁场产生方法的影响。结果表明，旋转磁场在产生热量方面比交变磁场更有效。然而，效率的程度取决于磁铁矿纳米粒子的排列。与交变磁场相比，旋转磁场的效率差异在单个纳米粒子（以磁流体的形式）中更为明显，而在包含链状纳米粒子的系统（磁小体和磁流体与磁小体的混合物，比例为 1:1）中则不那么明显。
