Department of Chemical Engineering, University of Bath, Bath BA2 7AY, UK.
Nanoscale. 2018 Nov 15;10(44):20519-20525. doi: 10.1039/c8nr05946b.
Magnetic hyperthermia is a potential technique for cancer therapy that exploits heat generated by magnetic nanoparticles to kill cancerous cells. Many studies have shown that magnetic hyperthermia is effective at killing cancer cells both in vitro and in vivo, however little attention has been paid to the cellular functioning of the surviving cells. We report here new evidence demonstrating the onset of thermally triggered differentiation in osteosarcoma cancer cells that survive magnetic hyperthermia treatment. This raises the possibility that in addition to causing cell death, magnetic hyperthermia could induce surviving cancer cells to form more mature cell types and thereby inhibit their capacity to self-renew. Such processes could prove to be as important as cell death when considering magnetic hyperthermia for treating cancer.
磁热疗是一种有潜力的癌症治疗技术，它利用磁性纳米粒子产生的热量来杀死癌细胞。许多研究表明，磁热疗在体外和体内都能有效地杀死癌细胞，然而，人们对幸存细胞的细胞功能关注甚少。我们在这里报告新的证据，证明在骨肉瘤癌细胞中，热触发分化的发生，这些细胞在接受磁热疗后幸存下来。这提出了一种可能性，即除了导致细胞死亡之外，磁热疗还可以诱导幸存的癌细胞形成更成熟的细胞类型，从而抑制其自我更新的能力。在考虑用磁热疗治疗癌症时，这些过程可能与细胞死亡一样重要。
