Alexander C D, Wetchler B V, Thompson R E
Can J Anaesth. 1987 Jul;34(4):362-5. doi: 10.1007/BF03010134.
Bupivacaine infiltration of the mesosalpinx was compared to lidocaine, normal saline or no injection for pain relief in women having elective laparoscopic tubal sterilization by Yoon fallopian ring application. One hundred women were assigned randomly to four groups. In a double-blind study, the mesosalpinx was infiltrated in three groups: Group 1 - lidocaine one per cent; Group II - bupivacaine 0.5 per cent; Group III - normal saline. Group IV (control) received no injection. Pain intensity was reported at four study times by the patients on a self-assessment pain intensity scale. Responses were compared using the Kruskall-Wallis H-Test and Wilcoxen's Rank-Sum Test. Both tests indicated significant differences in pain intensity levels at various study times. The amount of supplemental fentanyl given was used as a secondary measure of effectiveness. One-way analysis of variance (ANOVA) and Duncan's Multiple-Range Test showed the bupivacaine group to receive significantly less fentanyl (p less than 0.05) in the postanaesthesia care unit.
通过应用尹氏输卵管环进行择期腹腔镜输卵管绝育术的女性中，将布比卡因对输卵管系膜的浸润与利多卡因、生理盐水或不注射进行比较，以缓解疼痛。100名女性被随机分为四组。在一项双盲研究中，对三组进行输卵管系膜浸润：第一组——1%利多卡因；第二组——0.5%布比卡因；第三组——生理盐水。第四组（对照组）不进行注射。患者在四个研究时间点通过自我评估疼痛强度量表报告疼痛强度。使用克鲁斯卡尔 - 沃利斯H检验和威尔科克森秩和检验比较反应。两项检验均表明在不同研究时间点疼痛强度水平存在显著差异。给予的补充芬太尼量用作有效性的次要衡量指标。单因素方差分析（ANOVA）和邓肯多重范围检验显示，在麻醉后护理单元中，布比卡因组接受的芬太尼明显较少（p小于0.05）。
