Wittels B, Faure E A, Chavez R, Moawad A, Ismail M, Hibbard J, Principe D, Karl L, Toledano A Y
Department of Anesthesia and Critical Care, University of Chicago, Illinois 60637, USA.
Anesth Analg. 1998 Sep;87(3):619-23. doi: 10.1097/00000539-199809000-00024.
Postpartum bilateral tubal ligation is a brief surgical procedure with minimal tissue injury, yet postoperative recovery times and analgesia requirements are often disproportionately large. To evaluate the analgesic efficacy of local anesthetic infiltration, 20 parturients scheduled for elective minilaparotomy and bilateral tubal ligation with either spinal or epidural anesthesia participated in this prospective, randomized, controlled, double-blind trial. All patients received IV metoclopramide 10 mg and ketorolac 60 mg intraoperatively, as well as preincisional infiltration of the infraumbilical skin incision with 0.5% bupivacaine. Infiltration of bilateral uterine tubes and mesosalpinx was performed with either 0.5% bupivacaine (n = 10) or isotonic sodium chloride solution (saline) (n = 10). IV meperidine (25 mg every 3 min as needed) was given to treat pain in the postanesthesia care unit (PACU). The total amount of meperidine administered in the PACU was significantly larger in the saline group than in the bupivacaine group. Pain scores at 30, 45, 60, 75, and 90 min postoperatively and on the seventh postoperative day were significantly lower in the bupivacaine group than in the saline group. During tubal ligation, infiltration of uterine tubes and mesosalpinx with 0.5% bupivacaine significantly enhanced analgesia both in the immediate postoperative setting and on the seventh postoperative day compared with infiltration with sodium chloride.
During bilateral tubal ligation with either spinal or epidural anesthesia, preemptive analgesia using IV ketorolac, IV metoclopramide, and infiltration of the incised skin and uterine tubes with 0.5% bupivacaine allowed 9 of 10 patients to recover with no pain, nausea, vomiting, or cramping and to maintain good analgesia for 7 days postoperatively.
产后双侧输卵管结扎是一种手术操作简单、组织损伤极小的手术,但术后恢复时间和镇痛需求往往极不相称。为评估局部麻醉药浸润的镇痛效果,20例计划行择期小切口剖腹术及双侧输卵管结扎术、采用脊麻或硬膜外麻醉的产妇参与了这项前瞻性、随机、对照、双盲试验。所有患者术中均接受静脉注射甲氧氯普胺10毫克和酮咯酸60毫克,以及用0.5%布比卡因对脐下皮肤切口进行切开前浸润。双侧输卵管和输卵管系膜用0.5%布比卡因(n = 10)或等渗氯化钠溶液(生理盐水)(n = 10)进行浸润。在麻醉后护理单元(PACU),根据需要每3分钟静脉注射哌替啶25毫克以治疗疼痛。生理盐水组在PACU给予的哌替啶总量显著多于布比卡因组。布比卡因组术后30、45、60、75和90分钟以及术后第七天的疼痛评分显著低于生理盐水组。与用氯化钠浸润相比,在输卵管结扎期间,用0.5%布比卡因浸润输卵管和输卵管系膜在术后即刻及术后第七天均显著增强了镇痛效果。
在脊麻或硬膜外麻醉下行双侧输卵管结扎术时,采用静脉注射酮咯酸、静脉注射甲氧氯普胺以及用0.5%布比卡因浸润切开的皮肤和输卵管进行超前镇痛,使10例患者中有9例恢复时无疼痛、恶心、呕吐或痉挛,并在术后7天维持良好的镇痛效果。