Department of Nursing, Fujian Medical University Union Hospital, Fuzhou, China.
Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
J Clin Nurs. 2023 Jul;32(13-14):3852-3862. doi: 10.1111/jocn.16515. Epub 2022 Sep 8.
To investigate, for the first time, aberrant time-varying local brain activity in nurses following night shift-related sleep deprivation (SD) and its association with memory decline.
Prior studies have elucidated alterations in static local brain activity resulting from SD in the occupations outside medical profession.
A longitudinal study followed the STROBE recommendations.
Twenty female nurses underwent resting-state functional magnetic resonance imaging and memory function assessment (by Complex Figure Test (CFT) and the California Verbal Learning Test, Second Edition (CVLT-II)) twice, once in a rested wakefulness (RW) state and another after SD. By combining the sliding-window approach and amplitude of low-frequency fluctuation (ALFF) analysis, the dynamic ALFF (dALFF) variability was calculated to reflect the characteristics of dynamic local brain activity.
Poor performance on the CFT and CVLT-II was observed in nurses with night shift-related SD. Reduced dALFF variability was found in a set of cognition-related brain regions (including the medial/middle/superior frontal gyrus, anterior/posterior cingulate gyrus, precuneus, angular gyrus, orbitofrontal and subgenual areas, and posterior cerebellum lobe), while increased dALFF variability was observed in the somatosensory-related, visual and auditory regions. SD-related dALFF variability alterations correlated with changes in subjects' performance on the CFT and CVLT-II.
Night shift-related SD disturbed dynamic brain activity in high cognitive regions and induced compensatory reactions in primary perceptual cortex. Identifying dALFF variability abnormalities may broaden our understanding of neural substrates underlying SD-related cognitive alterations, especially memory dysfunction.
Night shift-related SD is as an important occupational hazard affecting brain function in nurses. The effective countermeasure addressing the adverse outcomes of SD should be advocated for nurses.
Patients or public were not involved in the design and implementation of the study or the analysis and interpretation of the data.
首次调查夜班相关睡眠剥夺（SD）后护士的异常时变局部脑活动及其与记忆减退的关系。
先前的研究已经阐明了职业外医学领域 SD 导致的静态局部脑活动变化。
遵循 STROBE 建议的纵向研究。
20 名女性护士接受了两次静息状态功能磁共振成像和记忆功能评估（通过复杂图形测试（CFT）和加利福尼亚语言学习测试第二版（CVLT-II）），一次在休息清醒状态（RW），另一次在 SD 后。通过结合滑动窗口方法和低频振幅（ALFF）分析，计算动态 ALFF（dALFF）变异性，以反映动态局部脑活动的特征。
夜班相关 SD 的护士在 CFT 和 CVLT-II 上表现较差。在一组与认知相关的脑区（包括内侧/中/额上回、前后扣带回、楔前叶、角回、眶额和 subgenual 区以及后小脑叶）中发现 dALFF 变异性降低，而在躯体感觉相关、视觉和听觉区域中观察到增加的 dALFF 变异性。SD 相关的 dALFF 变异性改变与受试者在 CFT 和 CVLT-II 上的表现变化相关。
夜班相关的 SD 扰乱了高认知区域的动态脑活动，并在初级感知皮层引起了代偿反应。确定 dALFF 变异性异常可能会拓宽我们对 SD 相关认知改变的神经基础的理解，特别是记忆功能障碍。
夜班相关的 SD 是影响护士大脑功能的重要职业危害。应倡导针对护士的 SD 不良后果的有效对策。
患者或公众未参与研究的设计和实施、数据的分析和解释。
