Zhang Qin, Hou Yong-Zhe, Ding Hui, Shu Yan-Ping, Li Jing, Chen Xi-Zhao, Li Jia-Lin, Lou Qin, Wang Dai-Xing
Department of Radiology, The Second People's Hospital of Guizhou Province, Guiyang 550000, Guizhou Province, China.
Department of Radiology, Guizhou Provincial People's Hospital, Guiyang 550000, Guizhou Province, China.
World J Psychiatry. 2024 Feb 19;14(2):315-329. doi: 10.5498/wjp.v14.i2.315.
Sleep deprivation is a prevalent issue that impacts cognitive function. Although numerous neuroimaging studies have explored the neural correlates of sleep loss, inconsistencies persist in the reported results, necessitating an investigation into the consistent brain functional changes resulting from sleep loss.
To establish the consistency of brain functional alterations associated with sleep deprivation through systematic searches of neuroimaging databases. Two meta-analytic methods, signed differential mapping (SDM) and activation likelihood estimation (ALE), were employed to analyze functional magnetic resonance imaging (fMRI) data.
A systematic search performed according to PRISMA guidelines was conducted across multiple databases through July 29, 2023. Studies that met specific inclu-sion criteria, focused on healthy subjects with acute sleep deprivation and reported whole-brain functional data in English were considered. A total of 21 studies were selected for SDM and ALE meta-analyses.
Twenty-one studies, including 23 experiments and 498 subjects, were included. Compared to pre-sleep deprivation, post-sleep deprivation brain function was associated with increased gray matter in the right corpus callosum and decreased activity in the left medial frontal gyrus and left inferior parietal lobule. SDM revealed increased brain functional activity in the left striatum and right central posterior gyrus and decreased activity in the right cerebellar gyrus, left middle frontal gyrus, corpus callosum, and right cuneus.
This meta-analysis consistently identified brain regions affected by sleep deprivation, notably the left medial frontal gyrus and corpus callosum, shedding light on the neuropathology of sleep deprivation and offering insights into its neurological impact.
睡眠剥夺是一个影响认知功能的普遍问题。尽管众多神经影像学研究已探索了睡眠缺失的神经关联，但报告结果仍存在不一致之处，因此有必要对睡眠缺失导致的一致脑功能变化进行调查。
通过对神经影像学数据库的系统检索，确定与睡眠剥夺相关的脑功能改变的一致性。采用两种元分析方法，即符号差异映射（SDM）和激活可能性估计（ALE），来分析功能磁共振成像（fMRI）数据。
根据PRISMA指南进行的系统检索在多个数据库中持续到2023年7月29日。纳入符合特定纳入标准、聚焦于急性睡眠剥夺的健康受试者且以英文报告全脑功能数据的研究。共选择21项研究进行SDM和ALE元分析。
纳入21项研究，包括23项实验和498名受试者。与睡眠剥夺前相比，睡眠剥夺后脑功能与右侧胼胝体灰质增加以及左侧内侧前额叶皮质和左侧顶下小叶活动减少有关。SDM显示左侧纹状体和右侧中央后回脑功能活动增加，右侧小脑回、左侧额中回、胼胝体和右侧楔叶活动减少。
这项元分析一致确定了受睡眠剥夺影响的脑区，特别是左侧内侧前额叶皮质和胼胝体，揭示了睡眠剥夺的神经病理学，并为其神经学影响提供了见解。
