Rotenberg Z, Weinberger I, Sagie A, Fuchs J, Sperling O, Agmon J
Clin Chem. 1987 Aug;33(8):1419-20.
Lactate dehydrogenase (LD, EC 1.1.1.27) isoenzymes 1 and 2 and the LD 1:2 ratio were determined in 62 patients with recent myocardial infarction 24, 48, and 72 h after total serum LD activity had returned to normal values. From the results we could define two groups of patients. The first, 40 patients in whom proportions of LD-1 and LD-2 isoenzymes in serum and the LD 1:2 ratio were all within the normal reference interval, all had an uncomplicated course of recovery from myocardial infarction. In the remaining 22 patients, LD-1 still exceeded LD-2 24 to 72 h after total LD activity returned to normal values; i.e., the ratio was similar to that in patients with myocardial infarction. Seven of these 22 patients (32%) had a complicated course, with re-infarction in all seven. Thus, even in the presence of normal total LD activity, a high LD 1:2 ratio may reflect a consistent focal myocardial necrosis in some patients with recent myocardial infarction and may serve as an early marker for further re-infarction.
在62例近期发生心肌梗死的患者中，于总血清乳酸脱氢酶（LD，EC 1.1.1.27）活性恢复至正常水平后24、48和72小时，测定了乳酸脱氢酶同工酶1和2以及LD 1:2比值。根据结果，我们可以将患者分为两组。第一组有40例患者，其血清中LD-1和LD-2同工酶的比例以及LD 1:2比值均在正常参考区间内，所有这些患者心肌梗死恢复过程均无并发症。在其余22例患者中，总LD活性恢复至正常水平后24至72小时，LD-1仍超过LD-2；也就是说，该比值与心肌梗死患者的比值相似。这22例患者中有7例（32%）病程复杂，7例均再次发生梗死。因此，即使总LD活性正常，高LD 1:2比值在一些近期发生心肌梗死的患者中可能反映持续存在的局灶性心肌坏死，并且可能作为进一步再梗死的早期标志物。
