Onyishi Nnaemeka T, Ohayi Samuel R
Histopathology Department, Enugu State University College of Medicine Parklane, Enugu, Nigeria.
J Skin Cancer. 2022 Aug 30;2022:5014610. doi: 10.1155/2022/5014610. eCollection 2022.
To estimate the prevalence of cutaneous SCC and BCC in all histologically confirmed skin cancer lesions in African albinos.The following five databases are as follows: African Journals Online (AJOL), PubMed, Europe PMC, and Google Scholar were searched for relevant articles. Study Selection: included studies were case series and cross-sectional studies of histologically confirmed skin cancers in African albinos. Data extraction and synthesis: data extraction and synthesis was informed by the meta-analysis of observational studies in epidemiology guideline. By random effect meta-analysis, we calculated the pooled prevalence of SCC and BCC in skin cancer lesions of the African albinos.
We abstracted 695 skin cancer lesions from 540 African albinos (275 male and 241 female albinos with sex not stated in 24 subjects). There were 419 SCCs and 249 BCCs. By meta-analysis, the pooled prevalence of SCC is 64% (95% CI; 50-77%). The prevalence for BCC is 31% (95% CI; 19-45%).
Overall, squamous cell carcinoma is the predominant type of keratinocyte carcinoma reported in African albinos. SCC is preponderant in case series of surgical excision biopsies while BCC predominates in studies reporting on albino skin surveillance programmes.
评估非洲白化病患者经组织学确诊的所有皮肤癌病变中皮肤鳞状细胞癌（SCC）和基底细胞癌（BCC）的患病率。检索了以下五个数据库：非洲在线期刊（AJOL）、PubMed、欧洲生物医学中心（Europe PMC）和谷歌学术，以查找相关文章。研究选择：纳入的研究为非洲白化病患者经组织学确诊的皮肤癌病例系列和横断面研究。数据提取与综合：数据提取与综合依据流行病学指南中观察性研究的荟萃分析进行。通过随机效应荟萃分析，我们计算了非洲白化病患者皮肤癌病变中SCC和BCC的合并患病率。
我们从540名非洲白化病患者（275名男性和241名女性，24名患者未注明性别）中提取了695个皮肤癌病变。其中有419个SCC和249个BCC。通过荟萃分析，SCC的合并患病率为64%（95%可信区间；50 - 77%）。BCC的患病率为31%（95%可信区间；19 - 45%）。
总体而言，鳞状细胞癌是非洲白化病患者中报告的主要类型的角质形成细胞癌。在手术切除活检的病例系列中SCC占优势，而在关于白化病皮肤监测项目的研究中BCC占主导。
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