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肯尼亚白化病患者中常见的恶性皮肤疾病。

Common malignant cutaneous conditions among albinos in Kenya.

作者信息

Emadi Seyed Emad, Juma Suleh Andrew, Babamahmoodi Farhang, Ahangarkani Fatemeh, Betty Chelimo Vanessa, Mutai Beatrice, Raeeskarami Seyyed Reza, Ghanadan Alireza, Emadi Seyed Naser

机构信息

Mazandaran University of Medical Sciences, Sari, & Iranian Red Crescent Society, Tehran, Iran.

Mbagathi District Hospital, University of Nairobi, Nairobi, Kenya.

出版信息

Med J Islam Repub Iran. 2017 Jan 11;31:3. doi: 10.18869/mjiri.31.3. eCollection 2017.

Abstract

Albinos in Africa are at constant risk of developing skin cancer due to the damage caused by ultra-violet exposure. This study identifies the common skin conditions among albinos in Kenya as a country located along the equator. In this descriptive study on albino patients who were admitted to Mbagathi District Hospital in Nairobi, Kenya the census method was used for sampling and a total of 151 albinos were registered. All necessary data including age, gender, type, site and the number of skin lesions were recorded. Suspected patients with malignant and premalignant lesions were studied individually through skin biopsy and histopathological investigation. Finally, the collected data were analyzed using SPSS software. Albinos with serious skin lesions were 121(80%) patients. Females were 64 (52.9%). The frequency of the following premalignant and malignant skin lesions including actinic-cheilitis, solar elastosis, actinic keratosis (AK), basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) were 17.88%, 11.92%, 37.08%, 7.94% and 5.29%, respectively. Hands (20.52%), face (19.20%), head (18.18%), shoulder (14.56%) and neck (7.94%) were the most affected areas by malignant and premalignant lesions. BCC was the most common type of cutaneous malignancy on the face and shoulders while AK was the most common cutaneous pre-malignancy on the hands and face in albinos in Kenya. Therefore, appropriate physical protection, avoiding any trauma when carrying sharp, heavy or rough instruments by the shoulder and hands, and finally urgent and quality treatment for any lesion even a small erosion and ulcer, especially on exposed areas in albinos, are recommended.

摘要

由于紫外线照射造成的损害,非洲的白化病患者一直面临患皮肤癌的风险。本研究确定了位于赤道沿线的肯尼亚白化病患者中常见的皮肤状况。在这项针对肯尼亚内罗毕姆巴加蒂区医院收治的白化病患者的描述性研究中,采用普查方法进行抽样,共登记了151名白化病患者。记录了所有必要的数据,包括年龄、性别、皮肤病变的类型、部位和数量。对疑似患有恶性和癌前病变的患者通过皮肤活检和组织病理学检查进行单独研究。最后,使用SPSS软件对收集的数据进行分析。有严重皮肤病变的白化病患者为121例(80%)。女性为64例(52.9%)。以下癌前和恶性皮肤病变的发生率,包括光化性唇炎、日光性弹性组织变性、光化性角化病(AK)、基底细胞癌(BCC)和鳞状细胞癌(SCC)分别为17.88%、11.92%、37.08%、7.94%和5.29%。手(20.52%)、面部(19.20%)、头部(18.18%)、肩部(14.56%)和颈部(7.94%)是受恶性和癌前病变影响最严重的部位。在肯尼亚白化病患者中,BCC是面部和肩部最常见的皮肤恶性肿瘤类型,而AK是手部和面部最常见的皮肤癌前病变。因此,建议采取适当的物理防护措施,在肩部和手部携带尖锐、沉重或粗糙器械时避免任何创伤,最后对任何病变,即使是小的糜烂和溃疡,尤其是白化病患者暴露部位的病变,进行紧急和高质量的治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1063/5473011/f1a2610e2bab/mjiri-31-3-g001.jpg

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