Department of Dermatology, Regional Dermatology Training Center, P,O, Box 8332, Moshi, Tanzania.
BMC Cancer. 2014 Mar 6;14:157. doi: 10.1186/1471-2407-14-157.
Skin cancer is rare among Africans and albinism is an established risk for skin cancer in this population. Ultraviolet radiation is highest at the equator and African albinos living close to the equator have the highest risk of developing skin cancers.
This was a retrospective study that involved histological review of all specimens with skin cancers from African albinos submitted to The Regional Dermatology Training Center in Moshi, Tanzania from 2002 to 2011.
A total of 134 biopsies from 86 patients with a male to female ratio of 1:1 were reviewed. Head and neck was the commonest (n = 75, 56.0%) site affected by skin cancers. Squamous cell carcinoma (SCC) was more common than basal cell carcinoma (BCC) with a ratio of 1.2:1. Only one Acral lentiginous melanoma was reported. Majority (55.6%) of SCC were well differentiated while nodular BCC (75%) was the most common type of BCC.
Squamous cell carcinoma is more common than basal cell carcinoma in African albinos.
皮肤癌在非洲人中较为罕见，而白化病是该人群皮肤癌的既定风险因素。紫外线辐射在赤道地区最高，居住在接近赤道的非洲白化病患者罹患皮肤癌的风险最高。
这是一项回顾性研究，涉及对 2002 年至 2011 年期间从坦桑尼亚莫希地区皮肤病学培训中心提交的所有非洲白化病患者皮肤癌标本进行组织学检查。
共回顾了 86 名患者的 134 份活检标本，男女比例为 1:1。头颈部是最常见的（n = 75，56.0%）受皮肤癌影响的部位。鳞状细胞癌（SCC）比基底细胞癌（BCC）更常见，比例为 1.2:1。仅报告了一例肢端雀斑样黑色素瘤。大多数（55.6%）SCC 分化良好，而结节性 BCC（75%）是最常见的 BCC 类型。
在非洲白化病患者中，鳞状细胞癌比基底细胞癌更为常见。
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