• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

FERONIA通过雷帕霉素靶蛋白（TOR）发挥作用，对自噬进行负调控。

FERONIA functions through Target of Rapamycin (TOR) to negatively regulate autophagy.

作者信息

Wang Ping, Clark Natalie M, Nolan Trevor M, Song Gaoyuan, Whitham Olivia G, Liao Ching-Yi, Montes-Serey Christian, Bassham Diane C, Walley Justin W, Yin Yanhai, Guo Hongqing

机构信息

Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA, United States.

Department of Plant Pathology and Microbiology, Iowa State University, Ames, IA, United States.

出版信息

Front Plant Sci. 2022 Aug 23;13:961096. doi: 10.3389/fpls.2022.961096. eCollection 2022.

DOI:10.3389/fpls.2022.961096
PMID:36082288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9446147/
Abstract

FERONIA (FER) receptor kinase plays versatile roles in plant growth and development, biotic and abiotic stress responses, and reproduction. Autophagy is a conserved cellular recycling process that is critical for balancing plant growth and stress responses. Target of Rapamycin (TOR) has been shown to be a master regulator of autophagy. Our previous multi-omics analysis with loss-of-function mutant implicated that FER functions in the autophagy pathway. We further demonstrated here that the mutant displayed constitutive autophagy, and FER is required for TOR kinase activity measured by S6K1 phosphorylation and by root growth inhibition assay to TOR kinase inhibitor AZD8055. Taken together, our study provides a previously unknown mechanism by which FER functions through TOR to negatively regulate autophagy.

摘要

FERONIA（FER）受体激酶在植物生长发育、生物和非生物胁迫响应以及繁殖过程中发挥着多种作用。自噬是一种保守的细胞循环过程，对于平衡植物生长和胁迫响应至关重要。雷帕霉素靶蛋白（TOR）已被证明是自噬的主要调节因子。我们之前对功能缺失突变体的多组学分析表明FER在自噬途径中发挥作用。我们在此进一步证明，该突变体表现出组成型自噬，并且通过S6K1磷酸化和根生长抑制试验检测TOR激酶活性时，FER是TOR激酶活性所必需的，该试验使用了TOR激酶抑制剂AZD8055。综上所述，我们的研究提供了一种此前未知的机制，即FER通过TOR负向调节自噬。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1422/9446147/828d7b6ae76e/fpls-13-961096-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1422/9446147/9ed7289687d9/fpls-13-961096-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1422/9446147/c1e7ec150e61/fpls-13-961096-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1422/9446147/d4de95c32a7b/fpls-13-961096-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1422/9446147/66031d2085f0/fpls-13-961096-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1422/9446147/dc95424a862e/fpls-13-961096-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1422/9446147/54e24cd786be/fpls-13-961096-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1422/9446147/828d7b6ae76e/fpls-13-961096-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1422/9446147/9ed7289687d9/fpls-13-961096-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1422/9446147/c1e7ec150e61/fpls-13-961096-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1422/9446147/d4de95c32a7b/fpls-13-961096-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1422/9446147/66031d2085f0/fpls-13-961096-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1422/9446147/dc95424a862e/fpls-13-961096-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1422/9446147/54e24cd786be/fpls-13-961096-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1422/9446147/828d7b6ae76e/fpls-13-961096-g007.jpg

相似文献

1
FERONIA functions through Target of Rapamycin (TOR) to negatively regulate autophagy.FERONIA通过雷帕霉素靶蛋白（TOR）发挥作用，对自噬进行负调控。
Front Plant Sci. 2022 Aug 23;13:961096. doi: 10.3389/fpls.2022.961096. eCollection 2022.
2
Integrated omics reveal novel functions and underlying mechanisms of the receptor kinase FERONIA in Arabidopsis thaliana.整合组学揭示受体激酶 FERONIA 在拟南芥中的新功能和潜在机制。
Plant Cell. 2022 Jul 4;34(7):2594-2614. doi: 10.1093/plcell/koac111.
3
The RALF1-FERONIA complex interacts with and activates TOR signaling in response to low nutrients.RALF1-FERONIA 复合物与 TOR 信号相互作用，并在响应低营养时激活该信号。
Mol Plant. 2022 Jul 4;15(7):1120-1136. doi: 10.1016/j.molp.2022.05.004. Epub 2022 May 17.
4
FERONIA interacts with ABI2-type phosphatases to facilitate signaling cross-talk between abscisic acid and RALF peptide in Arabidopsis.FERONIA与ABI2型磷酸酶相互作用，以促进拟南芥中脱落酸和RALF肽之间的信号串扰。
Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5519-27. doi: 10.1073/pnas.1608449113. Epub 2016 Aug 26.
5
Brassinosteroids modulate autophagy through phosphorylation of RAPTOR1B by the GSK3-like kinase BIN2 in Arabidopsis.油菜素内酯通过 GSK3 样激酶 BIN2 对拟南芥 RAPTOR1B 的磷酸化来调节自噬。
Autophagy. 2023 Apr;19(4):1293-1310. doi: 10.1080/15548627.2022.2124501. Epub 2022 Sep 24.
6
How a single receptor-like kinase exerts diverse roles: lessons from FERONIA.单个类受体激酶如何发挥多种作用：来自FERONIA的启示。
Mol Hortic. 2022 Nov 18;2(1):25. doi: 10.1186/s43897-022-00046-9.
7
TOR-Dependent and -Independent Pathways Regulate Autophagy in .TOR 依赖和非依赖途径在……中调节自噬。 （原文句子不完整，翻译可能不太准确，需结合完整文本理解）
Front Plant Sci. 2017 Jul 11;8:1204. doi: 10.3389/fpls.2017.01204. eCollection 2017.
8
FERONIA Receptor Kinase at the Crossroads of Hormone Signaling and Stress Responses.费罗尼亚受体激酶处于激素信号传导与应激反应的交叉点。
Plant Cell Physiol. 2017 Jul 1;58(7):1143-1150. doi: 10.1093/pcp/pcx048.
9
A temperature-sensitive FERONIA mutant allele that alters root hair growth.一个温度敏感的 FERONIA 突变等位基因，改变了根毛的生长。
Plant Physiol. 2021 Mar 15;185(2):405-423. doi: 10.1093/plphys/kiaa051.
10
FERONIA mutation induces high levels of chloroplast-localized Arabidopsides which are involved in root growth.FERONIA 突变诱导高水平的质体定位拟南芥，其参与根生长。
Plant J. 2019 Jan;97(2):341-351. doi: 10.1111/tpj.14123. Epub 2018 Nov 5.

引用本文的文献

1
Autophagy in plants.植物中的自噬作用。
Autophagy Rep. 2024 Oct 15;3(1):2395731. doi: 10.1080/27694127.2024.2395731. eCollection 2024.
2
is involved in root hair development in .参与了……中根毛的发育。 （原句不完整，信息缺失，此为根据现有内容的翻译）
Plant Signal Behav. 2025 Dec;20(1):2507736. doi: 10.1080/15592324.2025.2507736. Epub 2025 May 19.
3
FERONIA: A Malectin-Domain Receptor Kinase with Intricate Signaling Mechanisms and Profound Importance to Plant Wellness.FERONIA：一种具有复杂信号传导机制且对植物健康至关重要的类Malectin结构域受体激酶

本文引用的文献

1
Cell surface receptor kinase FERONIA linked to nutrient sensor TORC signaling controls root hair growth at low temperature linked to low nitrate in Arabidopsis thaliana.细胞表面受体激酶 FERONIA 与营养传感器 TORC 信号相连，控制拟南芥在低温和低硝酸盐条件下的根毛生长。
New Phytol. 2023 Apr;238(1):169-185. doi: 10.1111/nph.18723. Epub 2023 Jan 30.
2
Touch signaling and thigmomorphogenesis are regulated by complementary CAMTA3- and JA-dependent pathways.触摸信号传导和机械形态建成由互补的钙调蛋白3（CAMTA3）和茉莉酸（JA）依赖性途径调控。
Sci Adv. 2022 May 20;8(20):eabm2091. doi: 10.1126/sciadv.abm2091.
3
The RALF1-FERONIA complex interacts with and activates TOR signaling in response to low nutrients.
Yale J Biol Med. 2025 Mar 31;98(1):53-68. doi: 10.59249/PWYT9677. eCollection 2025 Mar.
4
Jack of all trades: crosstalk between FERONIA signaling and hormone pathways.多面手：FERONIA信号与激素途径之间的相互作用
J Exp Bot. 2025 May 10;76(7):1907-1920. doi: 10.1093/jxb/eraf071.
5
FERONIA: A Receptor Kinase at the Core of a Global Signaling Network.FERONIA：全球信号网络的核心受体激酶。
Annu Rev Plant Biol. 2024 Jul;75(1):345-375. doi: 10.1146/annurev-arplant-102820-103424. Epub 2024 Jul 2.
6
How a single receptor-like kinase exerts diverse roles: lessons from FERONIA.单个类受体激酶如何发挥多种作用：来自FERONIA的启示。
Mol Hortic. 2022 Nov 18;2(1):25. doi: 10.1186/s43897-022-00046-9.
RALF1-FERONIA 复合物与 TOR 信号相互作用，并在响应低营养时激活该信号。
Mol Plant. 2022 Jul 4;15(7):1120-1136. doi: 10.1016/j.molp.2022.05.004. Epub 2022 May 17.
4
Interactions between autophagy and phytohormone signaling pathways in plants.植物中自噬与植物激素信号通路之间的相互作用。
FEBS Lett. 2022 Sep;596(17):2198-2214. doi: 10.1002/1873-3468.14355. Epub 2022 Apr 28.
5
Integrated omics reveal novel functions and underlying mechanisms of the receptor kinase FERONIA in Arabidopsis thaliana.整合组学揭示受体激酶 FERONIA 在拟南芥中的新功能和潜在机制。
Plant Cell. 2022 Jul 4;34(7):2594-2614. doi: 10.1093/plcell/koac111.
6
FERONIA Receptor Kinase Integrates with Hormone Signaling to Regulate Plant Growth, Development, and Responses to Environmental Stimuli.FERONIA受体激酶与激素信号整合以调控植物生长、发育及对环境刺激的响应。
Int J Mol Sci. 2022 Mar 29;23(7):3730. doi: 10.3390/ijms23073730.
7
Mechano-transduction via the pectin-FERONIA complex activates ROP6 GTPase signaling in Arabidopsis pavement cell morphogenesis.果胶-FERONIA 复合物通过机械转导激活拟南芥 pavement 细胞形态发生中的 ROP6 GTP 酶信号转导。
Curr Biol. 2022 Feb 7;32(3):508-517.e3. doi: 10.1016/j.cub.2021.11.031. Epub 2021 Dec 6.
8
Arabidopsis pavement cell morphogenesis requires FERONIA binding to pectin for activation of ROP GTPase signaling.拟南芥表皮细胞形态发生需要 FERONIA 结合果胶以激活 ROP GTPase 信号。
Curr Biol. 2022 Feb 7;32(3):497-507.e4. doi: 10.1016/j.cub.2021.11.030. Epub 2021 Dec 6.
9
Fighting salt or enemies: shared perception and signaling strategies.对抗盐分或敌人：共同认知与信号传递策略
Curr Opin Plant Biol. 2021 Dec;64:102120. doi: 10.1016/j.pbi.2021.102120. Epub 2021 Nov 30.
10
The F-box E3 ubiquitin ligase BAF1 mediates the degradation of the brassinosteroid-activated transcription factor BES1 through selective autophagy in Arabidopsis.F-box E3 泛素连接酶 BAF1 通过选择性自噬在拟南芥中介导油菜素内酯激活的转录因子 BES1 的降解。
Plant Cell. 2021 Nov 4;33(11):3532-3554. doi: 10.1093/plcell/koab210.