Brattig N W, Tischendorf F W, Albiez E J, Büttner D W, Berger J
Clin Immunol Immunopathol. 1987 Aug;44(2):149-59. doi: 10.1016/0090-1229(87)90062-6.
The relationship of peripheral lymphocyte subpopulations to the generalized and localized form of onchocerciasis has been studied in 43 Liberian (West African) patients. Typing revealed a significantly increased proportion of lymphocytes expressing interleukin 2 or transferrin receptors in the localized form of onchocerciasis (African sowda) when compared to subjects with a generalized form and those without signs of onchocerciasis. Patients with African sowda showed a higher number of helper/inducer T cells, a greater ratio of helper/inducer: suppressor/cytotoxic T cells, and an increased number of DR antigen-positive cells and lymphocytes with a natural killer cell phenotype. Furthermore, the serum concentrations of immunoglobulins, particularly IgE an IgG, and antifilarial antibodies were significantly elevated in sowda patients in comparison to the generalized form and the controls. These results indicate that both forms of onchocerciasis represent different immunological types of host responsiveness and that African sowda might be associated with an increased compartment of activated T lymphocytes.
在43名利比里亚（西非）患者中，研究了外周淋巴细胞亚群与盘尾丝虫病的全身性和局限性形式之间的关系。分型显示，与全身性盘尾丝虫病患者和无盘尾丝虫病体征的受试者相比，局限性盘尾丝虫病（非洲疖肿）患者中表达白细胞介素2或转铁蛋白受体的淋巴细胞比例显著增加。患有非洲疖肿的患者表现出更高数量的辅助/诱导性T细胞、更高的辅助/诱导性T细胞与抑制/细胞毒性T细胞比例，以及更多的DR抗原阳性细胞和具有自然杀伤细胞表型的淋巴细胞。此外，与全身性盘尾丝虫病患者和对照组相比，疖肿患者的免疫球蛋白，尤其是IgE和IgG以及抗丝虫抗体的血清浓度显著升高。这些结果表明，两种形式的盘尾丝虫病代表了宿主反应性的不同免疫类型，并且非洲疖肿可能与活化T淋巴细胞数量增加有关。
