Department of Endocrinology, The Affiliated Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang, China.
J Endocrinol Invest. 2023 Feb;46(2):405-413. doi: 10.1007/s40618-022-01917-0. Epub 2022 Sep 9.
To investigate the effect of aging on the prevalence of prediabetes and diabetes, and the influence of aging on the associations among adipose mass, redistribution, β cell function, and the prevalence of hyperglycaemia.
This urban-based cross-sectional study included 1033 Chinese Han people, aged 40-65 years. The abdominal subcutaneous fat area (SFA) and visceral fat area (VFA) were determined by magnetic resonance imaging. The prevalence rates of prediabetes and diabetes were analyzed according to age group (40-49, 50-59, and 60-65 years). The effects of aging on abdominal fat mass, adipose distribution, insulin action indexes were also assessed.
Prediabetes and diabetes prevalence gradually increased with age. Both SFA and VFA increased, while SFA/VFA decreased, in the 50-59 and 60-65 years age groups compared to the 40-49 years group. Homeostatic model assessment of insulin resistance (HOMA-IR) increased with fat mass. Homeostatic model assessment of beta-cell function (HOMA-β) and early-phase insulin secretion (∆I30/∆G30) were decreased in the 60-65 years group compared to the younger age groups. Increased age, VFA, and HOMA-IR, as well as decreased HOMA-β, were risk factors for the development of prediabetes and diabetes. The associations between central obesity and the development of prediabetes and diabetes, but not the associations of SFA/VFA, HOMA-IR, and HOMA-β with hyperglycaemia prevalence, weakened with age.
The prevalence of prediabetes and diabetes increased with age. Central obesity may be related stronger to the development of hyperglycaemia in younger people.
探讨衰老对糖尿病前期和糖尿病患病率的影响，以及衰老对脂肪量、分布变化、β细胞功能与高血糖患病率之间关联的影响。
本项基于城市的横断面研究纳入了 1033 名年龄在 40-65 岁的汉族中国人。采用磁共振成像技术测定腹部皮下脂肪面积（SFA）和内脏脂肪面积（VFA）。根据年龄组（40-49、50-59 和 60-65 岁）分析糖尿病前期和糖尿病的患病率。还评估了衰老对腹部脂肪量、脂肪分布、胰岛素作用指标的影响。
糖尿病前期和糖尿病的患病率随年龄增长而逐渐增加。与 40-49 岁组相比，50-59 岁和 60-65 岁组的 SFA 和 VFA 增加，而 SFA/VFA 减少。稳态模型评估的胰岛素抵抗（HOMA-IR）随脂肪量增加而增加。与年轻年龄组相比，60-65 岁组的稳态模型评估的β细胞功能（HOMA-β）和早期胰岛素分泌（∆I30/∆G30）降低。年龄增加、VFA 和 HOMA-IR 增加，以及 HOMA-β 降低是发生糖尿病前期和糖尿病的危险因素。中心性肥胖与糖尿病前期和糖尿病的发生之间存在关联，但 SFA/VFA、HOMA-IR 和 HOMA-β 与高血糖患病率之间的关联，随年龄增长而减弱。
糖尿病前期和糖尿病的患病率随年龄增长而增加。中心性肥胖与年轻人高血糖的发生可能更为相关。
