He Yingzi, Wang Jingjing, Wang Jianan, Qiu Ruojun, Wang Shuo, Jin Ting, Li Hong, Zheng Fenping
Department of Endocrinology, the Affiliated Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Zhejiang, 310016, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 Jun 21;17:2555-2569. doi: 10.2147/DMSO.S457455. eCollection 2024.
This study assessed possible associations among physical activity (PA), sitting time (ST), metabolic syndrome (MetS), and the individual components thereof. We analyzed the entire study sample and subpopulations stratified by visceral fat area (VFA). We hypothesized that individuals with elevated VFA might respond differently to modifiers of metabolic health, including PA and ST.
This cross-sectional study, conducted between March and May 2010, enrolled 957 adults with abdominal magnetic resonance imaging (MRI) aged 40-65 years living in the urban communities in Hangzhou, China. PA and ST were recorded using the standard International Physical Activity Questionnaire (IPAQ) and categorized into three levels. The ethnicity-specific cutoff for central obesity was VFA ≥ 80 cm on MRI according to Chinese population-based research. Multiple logistic regression models were used to analyze the associations between PA, ST, MetS and its components.
In the total subject population, participants reporting high level of PA were at a lower risk of MetS (OR = 0.46, 95% CI: 0.25, 0.86) than those declaring low PA. In the subgroup population with VFA ≥ 80 cm (ie, with central obesity), moderate-to-high PA levels were associated with a lower risk of MetS (p for trend < 0.05) and a lower risk of decreased high-density lipoprotein cholesterol (HDL-C) concentrations (p for trend < 0.05). In addition, ST > 3 h/day was a risk factor for both MetS (p for trend < 0.05) and hypertriglyceridemia (p for trend < 0.05) in the total subject population. While in the central obesity subgroup, ST > 3 h/day was found a stronger risk factor.
Our study suggests that moderate-to-high levels of PA may have a role in prevention of MetS, and ST > 3 h/day was associated with a higher risk of MetS, particularly in individuals with central obesity.
本研究评估了身体活动（PA）、久坐时间（ST）、代谢综合征（MetS）及其各个组成部分之间可能存在的关联。我们分析了整个研究样本以及按内脏脂肪面积（VFA）分层的亚人群。我们假设VFA升高的个体对代谢健康调节因素（包括PA和ST）的反应可能不同。
这项横断面研究于2010年3月至5月进行，纳入了957名年龄在40 - 65岁、居住在中国杭州城市社区且接受腹部磁共振成像（MRI）检查的成年人。使用标准的国际身体活动问卷（IPAQ）记录PA和ST，并将其分为三个水平。根据基于中国人群的研究，MRI上中心性肥胖的种族特异性切点为VFA≥80 cm²。使用多元逻辑回归模型分析PA、ST、MetS及其组成部分之间的关联。
在总研究人群中，报告高水平PA的参与者患MetS的风险（OR = 0.46，95% CI：0.25，0.86）低于报告低水平PA的参与者。在VFA≥80 cm²（即患有中心性肥胖）的亚组人群中，中等到高水平的PA与较低的MetS风险（趋势p < 0.05）和较低的高密度脂蛋白胆固醇（HDL-C）浓度降低风险（趋势p < 0.05）相关。此外，在总研究人群中，每天久坐时间> 3小时是MetS（趋势p < 0.05）和高甘油三酯血症（趋势p < 0.05）的危险因素。而在中心性肥胖亚组中，每天久坐时间> 3小时是更强的危险因素。
我们的研究表明，中等到高水平的PA可能在预防MetS中发挥作用，且每天久坐时间> 3小时与较高的MetS风险相关，尤其是在患有中心性肥胖的个体中。
