Neuron23, Inc, South San Francisco, CA, USA.
EvolveImmune Therapeutics, Branford, CT, USA.
Methods Mol Biol. 2022;2541:105-120. doi: 10.1007/978-1-0716-2545-3_15.
Large structurally diverse peptidomimetic chemical libraries have been very useful tools in chemical biology and drug discovery for the identification of therapeutically important compounds with higher affinity and improved pharmacological properties against different protein targets.Here we describe a simple and general method for the submonomer solid phase synthesis of large one bead-one compound (OBOC) peptidomimetic libraries of structurally diverse compounds that can be encoded by mass or genetic methods.
大型结构多样的肽模拟化学库在化学生物学和药物发现中是非常有用的工具，可用于鉴定对不同蛋白质靶标具有更高亲和力和改善的药理特性的治疗上重要的化合物。在这里，我们描述了一种用于亚单体制备固相合成结构多样的化合物的大型单珠-单化合物（OBOC）肽模拟文库的简单而通用的方法，这些化合物可以通过质量或遗传方法进行编码。
