Department of Radiobiology, Institute for Environmental Sciences, 1-7, Ienomae, Obuchi, Rokkasho-mura, Kamikita-gun, Aomori 039-3212, Japan.
Radiat Prot Dosimetry. 2022 Sep 9;198(13-15):985-989. doi: 10.1093/rpd/ncac025.
Research in the Department of Radiobiology at the Institute for Environmental Sciences (IES) has focused mainly on the biological effects of long-term low dose-rate radiation exposure on mice since its establishment 30 y ago. The IES has exposed thousands of mice of various strains, to gamma-rays, mostly chronically, at low dose-rates of 0.05, 1, 20 or 100 mGy/d, at medium dose-rates of 200 or 400 mGy/d or at acute high dose-rates of 0.7-0.9 Gy/min. The dose-rate 0.05 mGy/d is comparable with the dose limit for radiation workers of 100 mSv/5 y. The results will be presented based on the parameters examined at various endpoints such as life span, neoplasm (cancer incidence), chromosome aberrations frequencies, alterations in mRNA levels, tumour transplantability and developmental abnormalities after in utero exposures. The results from research collaborations with universities and institutions both domestic (within Japan) and international will be presented. Lastly, an outline of experiments (e.g. juvenile exposure, low dose tritium exposures) and projects (e.g. radiobiology archives) currently in progress and future research perspectives will be described.
该研究所环境科学系放射生物学部自 30 年前成立以来，主要专注于长期低剂量率辐射暴露对小鼠的生物学效应的研究。该研究所以各种品系的数千只小鼠为对象，主要采用慢性暴露方式，辐射剂量率分别为 0.05、1、20 或 100mGy/d，中剂量率为 200 或 400mGy/d，急性高剂量率为 0.7-0.9Gy/min。0.05mGy/d 的剂量率与辐射工作人员的 100mSv/5y 剂量限值相当。将根据生命跨度、肿瘤（癌症发病率）、染色体畸变频率、mRNA 水平变化、肿瘤移植能力和宫内暴露后的发育异常等各种终点检查的参数来呈现结果。将展示与国内外大学和机构的合作研究结果。最后，将介绍正在进行的实验（如幼年暴露、低剂量氚暴露）和项目（如放射生物学档案）的概况，并描述未来的研究方向。
