Department of Pure and Applied Physics, Kansai University, 3-3-35 Yamate-cho, Suita 564-8680, Japan.
Division of Sustainable Energy and Environmental Engineering, School of Engineering, Osaka University, 2-1 Yamada-oka, Suita 565-0871, Japan.
Radiat Prot Dosimetry. 2022 Sep 9;198(13-15):1155-1159. doi: 10.1093/rpd/ncac086.
The concept of radiation-induced aging is revisited from the viewpoint of a mathematical model. The effect of radiation on carcinogenesis is treated based on the Armitage-Doll multi-stage theory. The formula obtained for cancer incidence rate indicates that radiation dose can be explained in terms of time. Radiation-induced aging for acute and chronic exposures is described using age-specific cancer incidence rates as a measure of aging. It shows that accelerated aging is related to the dose rate, whereas premature aging is related to the cumulative dose, providing a simple and natural interpretation of radiation-induced aging. The usefulness of this approach is demonstrated by applying the formula to cancer prevalence data from mice chronically exposed to low dose-rate radiation.
从数学模型的角度重新审视了辐射诱导衰老的概念。基于 Armitage-Doll 多阶段理论，研究了辐射对致癌的影响。得出的癌症发病率公式表明，辐射剂量可以用时间来解释。以年龄特异性癌症发病率作为衰老的衡量标准，描述了急性和慢性暴露的辐射诱导衰老。结果表明，加速衰老与剂量率有关，而早衰与累积剂量有关，为辐射诱导衰老提供了一个简单自然的解释。通过将该公式应用于低剂量率辐射慢性暴露的小鼠的癌症流行数据，证明了该方法的有效性。
