Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 511443, China.
Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 511443, China; Research Center of Low Carbon Economy for Guangzhou Region, Key Laboratory of Philosophy and Social Science in Guangdong Province of Community of Life for Man and Nature, Jinan University, Guangzhou 510632, China.
J Hazard Mater. 2023 Jan 5;441:129819. doi: 10.1016/j.jhazmat.2022.129819. Epub 2022 Aug 24.
Data on the occurrences of legacy and alternative per- and polyfluoroalkyl substances (PFASs) in glioma are scarce. It remains unclear if PFASs exposure is related to the prevalence of glioma. A total of 137 glioma and 40 non-glioma brain tissue samples from patients recruited from the Nanfang Hospital, South China were analyzed for 17 PFAS compounds. Perfluorohexanoic acid, perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (FOSA), and 6:2 chlorinated polyfluorinated ether sulfonate were frequently detected (> 60 %) in glioma. The total concentrations (range; median) of 17 PFASs in glioma (0.20-140; 3.1 ng g) were slightly higher than those in non-glioma (0.35-32; 2.2 ng g), but without statistical significance. The PFAS concentrations in males were statistically higher (p < 0.05) than those in females. Elevated glioma grades were associated with higher concentrations of PFOA, PFOS, and FOSA. Positive correlations were observed between PFAS concentrations (especially for PFOA) and Ki-67 or P53 expression, pathological molecular markers of glioma. Our findings suggested that exposure to PFASs might increase the probability to develop glioma. This is the first case study demonstrating associations between PFASs exposure and brain cancer. More evidences and potential pathogenic mechanisms warranted further investigations.
关于神经胶质瘤中遗留和替代的全氟和多氟烷基物质 (PFAS) 的发生的数据很少。PFAS 暴露是否与神经胶质瘤的流行有关尚不清楚。从中国南方南方医院招募的 137 例神经胶质瘤和 40 例非神经胶质瘤脑组织样本中分析了 17 种 PFAS 化合物。全氟己酸、全氟辛酸 (PFOA)、全氟辛烷磺酸 (PFOS)、全氟辛烷磺酰胺 (FOSA) 和 6:2 氯代多氟醚磺酸在神经胶质瘤中经常被检测到（>60%）。神经胶质瘤中 17 种 PFAS 的总浓度（范围；中位数）（0.20-140；3.1ng/g）略高于非神经胶质瘤（0.35-32；2.2ng/g），但无统计学意义。男性的 PFAS 浓度（p<0.05）明显高于女性。升高的神经胶质瘤分级与 PFOA、PFOS 和 FOSA 的浓度升高有关。PFAS 浓度（尤其是 PFOA）与 Ki-67 或 P53 表达呈正相关，Ki-67 或 P53 是神经胶质瘤的病理分子标志物。我们的研究结果表明，PFAS 暴露可能会增加患神经胶质瘤的可能性。这是首例表明 PFAS 暴露与脑癌之间存在关联的病例研究。需要更多的证据和潜在的发病机制进一步研究。
