Hawker F H, Stewart P M, Baxter R C, Borkmann M, Tan K, Caterson I D, McWilliam D B
Crit Care Med. 1987 Aug;15(8):732-6. doi: 10.1097/00003246-198708000-00004.
Twenty ICU patients, with varying diagnoses and degrees of catabolism, were studied prospectively to determine whether somatomedin-C/insulin-like growth factor I (SMC/IGFI) is related to the conventional nutritional indices, plasma prealbumin, transferrin and albumin, and nitrogen balance (NB) in critical illness. Mean SMC/IGFI concentration in these critically ill patients was below the lower limit of the reference range. SMC/IGFI concentrations correlated with NB for the 24 h before measurement (r = .38, p less than .01) and with cumulative NB for the previous 2 (r = .50, p less than .01), 3 (r = .34, p less than .05), and 5 days (r = .46, p less than .05). Prealbumin correlated with cumulative 5-day NB (r = .39, p less than .05). Plasma albumin and transferrin concentrations did not correlate with NB for any of these time periods. SMC/IGFI concentrations correlated with cumulative protein (r = .59, p less than .01), carbohydrate (r = .63, p less than .01), and energy intake (r = .64, p less than .01). SMC/IGFI was the only index which consistently correlated with NB. We conclude it is a useful index of nutritional status in critically ill patients.
对20名诊断各异且分解代谢程度不同的重症监护病房患者进行了前瞻性研究，以确定生长调节素-C/胰岛素样生长因子I（SMC/IGFI）是否与危重病中的传统营养指标、血浆前白蛋白、转铁蛋白和白蛋白以及氮平衡（NB）相关。这些危重病患者的平均SMC/IGFI浓度低于参考范围的下限。SMC/IGFI浓度与测量前24小时的NB相关（r = 0.38，p < 0.01），与之前2天（r = 0.50，p < 0.01）、3天（r = 0.34，p < 0.05）和5天的累积NB相关（r = 0.46，p < 0.05）。前白蛋白与累积5天的NB相关（r = 0.39，p < 0.05）。在这些时间段中的任何一个，血浆白蛋白和转铁蛋白浓度均与NB不相关。SMC/IGFI浓度与累积蛋白质（r = 0.59，p < 0.01）、碳水化合物（r = 0.63，p < 0.01）和能量摄入（r = 0.64，p < 0.01）相关。SMC/IGFI是唯一始终与NB相关的指标。我们得出结论，它是危重病患者营养状况的一个有用指标。
