TP53突变在三阴性乳腺癌中的影响。
Impact of TP53 mutations in Triple Negative Breast Cancer.
作者信息
Mitri Zahi I, Abuhadra Nour, Goodyear Shaun M, Hobbs Evthokia A, Kaempf Andy, Thompson Alastair M, Moulder Stacy L
机构信息
Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
出版信息
NPJ Precis Oncol. 2022 Sep 9;6(1):64. doi: 10.1038/s41698-022-00303-6.
Identifying triple negative breast cancer (TNBC) patients expected to have poor outcomes provides an opportunity to enhance clinical management. We applied an Evolutionary Action Score to functionally characterize TP53 mutations (EAp53) in 96 TNBC patients and observed that EAp53 stratification may identify TP53 mutations associated with worse outcomes. These findings merit further exploration in larger TNBC cohorts and in patients treated with neoadjuvant chemotherapy regimens.
识别预期预后较差的三阴性乳腺癌（TNBC）患者为加强临床管理提供了契机。我们应用进化行动评分对96例TNBC患者的TP53突变进行功能特征分析（EAp53），并观察到EAp53分层可能识别出与更差预后相关的TP53突变。这些发现值得在更大的TNBC队列以及接受新辅助化疗方案治疗的患者中进一步探索。
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