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经等离子能量消融、囊肿切除术和引流术治疗子宫内膜异位症囊肿后妊娠率:一项三臂对照研究。

Pregnancy rate following endometriomas management by ablation using plasma energy, cystectomy and drainage: A three-arm comparative study.

机构信息

Department of Obstetrics and Gynecology, University of Medicine, Pharmacy, Science and Technology "George Emil Palade" Targu Mures, Targu Mures, Romania.

Expert Centre in the Diagnosis and Multidisciplinary Management of Endometriosis, Rouen University Hospital, Rouen, France.

出版信息

Int J Gynaecol Obstet. 2023 Mar;160(3):947-954. doi: 10.1002/ijgo.14444. Epub 2022 Sep 21.

Abstract

OBJECTIVE

To compare differences in the postoperative pregnancy rate in women seeking to conceive and presenting with endometriomas larger than 3 cm in diameter, which were managed by ablation using plasma energy, cystectomy, or simple drainage.

METHODS

A retrospective three-arm comparative study based on prospective collection of data evaluating 363 patients, undergoing endometrioma cystectomy, ablation using plasma energy, or simple drainage.

RESULTS

In this series, 204 (56.2%) patients underwent endometrioma ablation using plasma energy, 121 (33.3%) received cystectomy, and 38 (10.5%) had a simple drainage. Postoperative follow up was 50 ± 26 months. Overall postoperative pregnancy rate was 60.3%. The probability of being pregnant after cystectomy, ablation, and drainage was respectively 27%, 32%, and 16% at 12 months, with a statistically significant difference between pregnancy rates among the three arms (P = 0.015). Simple drainage was associated with a probability of conception over 50% after 2 years, mainly based on postoperative assisted reproductive technology.

CONCLUSIONS

We reveal good postoperative pregnancy rate after ablation using plasma energy or cystectomy for endometriomas. Surgical management should be carefully considered in women with endometriomas and pregnancy intention, because the postoperative pregnancy rate may be compared with that observed after first-line assisted reproductive technology management.

摘要

目的

比较直径大于 3cm 的子宫内膜异位症囊肿采用等离子能量消融术、囊肿切除术或单纯引流术治疗后妊娠率的差异。

方法

这是一项基于前瞻性数据收集的回顾性三臂比较研究,共评估了 363 例接受子宫内膜异位症囊肿切除术、等离子能量消融术或单纯引流术的患者。

结果

在本系列中,204 例(56.2%)患者接受了等离子能量消融术,121 例(33.3%)接受了囊肿切除术,38 例(10.5%)接受了单纯引流术。术后随访时间为 50±26 个月。总体术后妊娠率为 60.3%。囊肿切除术、消融术和引流术后 12 个月的妊娠概率分别为 27%、32%和 16%,三组间妊娠率存在统计学差异(P=0.015)。单纯引流术后 2 年妊娠概率超过 50%,主要得益于术后辅助生殖技术。

结论

我们发现子宫内膜异位症囊肿采用等离子能量消融术或囊肿切除术的术后妊娠率较高。对于有生育要求的子宫内膜异位症患者,应慎重考虑手术治疗,因为术后妊娠率可能与一线辅助生殖技术管理后的妊娠率相当。

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