Blondeau P, Lamarche J, Lafond G, Brunette J R
Curr Eye Res. 1987 Jun;6(6):747-56. doi: 10.3109/02713688709034841.
We studied the effect of optic nerve section on the pattern electroretinogram (PERG) of 10 pigeons. Base line PERG and flash ERG were measured prior to surgery and then one optic nerve was cut. We measured PERG at various time intervals up to 24 weeks after the section. There was a sharp drop in PERG amplitude immediately following the section. It gradually returned to normal levels in the following 24 weeks. Significant decreases in time to peak were noted at 1 and 16 weeks for 0.5 cycle per degree checks and at 1, 2 and 9 weeks for 0.25 cycle per degree checks. The ERG generated by a TV stimulus did not change in amplitude but had a shorter time to peak at 24 weeks for a high intensity stimulus and at 16, 18, 24 weeks for a low intensity stimulus. Light and electron microscopic sections (at 24 weeks) revealed an almost complete loss of nerve fibers in the optic nerve. Retinal sections revealed only a few surviving ganglion cells and a few nerve fibers. This suggests that in pigeons, PERG is not generated by ganglion cells.
我们研究了视神经切断术对10只鸽子图形视网膜电图（PERG）的影响。在手术前测量基础PERG和闪光视网膜电图（ERG），然后切断一条视神经。在切断后长达24周的不同时间间隔测量PERG。切断后PERG振幅立即急剧下降。在接下来的24周内逐渐恢复到正常水平。对于每度0.5个周期的检查，在第1周和第16周以及对于每度0.25个周期的检查，在第1周、第2周和第9周观察到峰值时间显著缩短。电视刺激产生的ERG振幅没有变化，但对于高强度刺激在第24周以及对于低强度刺激在第16周、第18周和第24周峰值时间缩短。光镜和电镜切片（在第24周）显示视神经中神经纤维几乎完全丧失。视网膜切片仅显示少数存活的神经节细胞和少数神经纤维。这表明在鸽子中，PERG不是由神经节细胞产生的。
