小鼠图形视网膜电图。
The mouse pattern electroretinogram.
作者信息
Porciatti Vittorio
机构信息
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
出版信息
Doc Ophthalmol. 2007 Nov;115(3):145-53. doi: 10.1007/s10633-007-9059-8. Epub 2007 May 24.
Abstract
Mouse models of optic nerve disease such as glaucoma, optic neuritis, ischemic optic neuropathy, and mitochondrial optic neuropathy are being developed at increasing rate to investigate specific pathophysiological mechanisms and the effect of neuroprotective treatments. The use of these models may be greatly enhanced by the availability of non-invasive methods able to monitor retinal ganglion cell (RGC) function longitudinally such as the Pattern Electroretinogram (PERG). While the use of the PERG as a tool to probe inner retina function in mammals is known since 25 years, relatively less information is available for the mouse. Here, the PERG technique and the main applications in the mouse are reviewed.
摘要
诸如青光眼、视神经炎、缺血性视神经病变和线粒体视神经病变等视神经疾病的小鼠模型正以越来越快的速度被开发出来，以研究特定的病理生理机制以及神经保护治疗的效果。能够纵向监测视网膜神经节细胞（RGC）功能的非侵入性方法，如图形视网膜电图（PERG）的出现，可能会大大提高这些模型的应用价值。虽然自25年前以来，人们就知道使用PERG作为探测哺乳动物视网膜内层功能的工具，但关于小鼠的相关信息相对较少。在此，对PERG技术及其在小鼠中的主要应用进行综述。
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