Camber O, Edman P, Gurny R
Curr Eye Res. 1987 Jun;6(6):779-84. doi: 10.3109/02713688709034844.
Sodium hyaluronate is a potential vehicle for drugs given topically to the eye. In the present study, the effect of sodium hyaluronate on the miosis induced by pilocarpine in rabbits was investigated. Addition of 0.2 and 0.75% sodium hyaluronate to 1% pilocarpine hydrochloride in buffer resulted in an increased effect measured as area under the miosis-time curve (AUC) and duration of miosis. A comparison between a commercially available 1% pilocarpine preparation and the preparations containing sodium hyaluronate showed that sodium hyaluronate improves the effect parameters. No adverse effects with sodium hyaluronate were observed. Possible mechanisms inducing these improvements are discussed.
透明质酸钠是一种用于眼部局部给药的潜在药物载体。在本研究中，研究了透明质酸钠对毛果芸香碱诱导家兔瞳孔缩小的影响。在缓冲液中将0.2%和0.75%的透明质酸钠添加到1%的盐酸毛果芸香碱中，以瞳孔缩小-时间曲线下面积（AUC）和瞳孔缩小持续时间衡量，结果显示效果增强。将市售1%毛果芸香碱制剂与含透明质酸钠的制剂进行比较，结果表明透明质酸钠改善了效果参数。未观察到透明质酸钠有不良反应。文中讨论了导致这些改善的可能机制。
