Annu Int Conf IEEE Eng Med Biol Soc. 2022 Jul;2022:5103-5106. doi: 10.1109/EMBC48229.2022.9871095.
Neurological disorders such as stroke remain leading causes of disability worldwide. A current thrust in the neurorehabilitation of such disorders involves exogenous neuromodulation of cranial nerves in order to enhance neuro-plasticity and maximize recovery of function. Here we present preliminary results on the effects of kilohertz range electrical stimulation of the trigeminal nerve (TNS) on motor learning, using an upper extremity visuomotor adaptation paradigm. Twenty-five (25) healthy adult subjects were randomly assigned to 2 groups: 3kHz stimulation ( n=13) and sham ( n=12). Participants performed a visuomotor rotation task that involved center-out reaching movements to eight vertically arranged targets. Four blocks of trials were performed: two baseline blocks with veridical visual feedback, one adaptation block involving a 30° CCW rotation of hand visual feedback, and one washout block with no rotation. TNS was applied for 20 minutes before the 2nd baseline block using two electrodes targeting the ophthalmic branches of the trigeminal nerve. Early in the rotation block, learning rates were similar between the 3kHz and sham groups but gradually diverged, with the 3kHz group demonstrating slightly faster rates than sham later in the rotation block. The results provide new information on the potential use of TNS in neurorehabilitation.
神经紊乱疾病,如中风,仍然是全球范围内导致残疾的主要原因。目前,此类疾病的神经康复的一个重点是对外源性颅神经进行神经调节,以增强神经可塑性并最大限度地恢复功能。在这里,我们介绍了使用上肢视觉运动适应范式,对三叉神经(TNS)进行千赫兹范围电刺激对运动学习影响的初步结果。25 名健康成年受试者被随机分为 2 组:3kHz 刺激组(n=13)和假刺激组(n=12)。参与者进行了一项视觉运动旋转任务,包括向 8 个垂直排列的目标进行中心外伸运动。进行了 4 个试验块:2 个具有真实视觉反馈的基线块,1 个涉及手视觉反馈逆时针旋转 30°的适应块,1 个没有旋转的洗脱块。在第二个基线块之前,使用两个针对三叉神经眼支的电极进行 20 分钟的 TNS 治疗。在旋转块的早期,3kHz 组和假刺激组的学习率相似,但逐渐出现分歧,3kHz 组在旋转块的后期显示出比假刺激组稍快的学习率。这些结果为 TNS 在神经康复中的潜在应用提供了新的信息。
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