Annu Int Conf IEEE Eng Med Biol Soc. 2022 Jul;2022:3919-3922. doi: 10.1109/EMBC48229.2022.9872001.
Functionality of neural implants can be seriously impaired by scarring during the foreign body reaction (FBR). Tailoring of the material-tissue interface is supposed to modulate part of the FBR. Surface structures might physically modulate the foreign body reaction in the acute phase directly after implantation. This work focuses on fabrication and characterization of bioinspired microtextures comprising reentrant cavities with non-wettable surface characteristics. The Selected microstructure patterns were fabricated using direct laser writing and were characterized by means of contact angle measurements and immersion tests. Clinical Relevance-Suggested by the outcome of this study, the proposed surface characteristics in neural interface can impact the wetting properties of the interface, hence, influence the interaction between the body fluid with the surface of the neural implant. Future studies should address the impact of the suggested design criterion and their applicability in improving the long-term stability of neural implants.
神经植入物的功能可能会因异物反应 (FBR) 期间的瘢痕形成而严重受损。通过调整材料-组织界面，可以调节异物反应的一部分。表面结构可能会在植入后的急性期直接对异物反应进行物理调节。这项工作专注于制造和表征包含具有不可润湿表面特性的凹入腔的仿生微纹理。使用直接激光写入制造选定的微结构图案，并通过接触角测量和浸入测试进行表征。临床相关性-根据这项研究的结果，神经界面中提出的表面特性可以影响界面的润湿性，从而影响体液与神经植入物表面之间的相互作用。未来的研究应解决建议的设计标准的影响及其在提高神经植入物长期稳定性方面的适用性。
