Ospedale Guglielmo da Saliceto, Piacenza, Italy.
Ospedale Guglielmo da Saliceto, Piacenza, Italy.
J Stroke Cerebrovasc Dis. 2022 Nov;31(11):106716. doi: 10.1016/j.jstrokecerebrovasdis.2022.106716. Epub 2022 Aug 10.
To assess whether COVID-19 could be a concurrent factor in the genesis and/or worsening of stroke and to provide data on COVID-19 -associated stroke patients during the first pandemic wave and comparative data on COVID-19 negative stroke patients in the same period.
This is a retrospective, observational, case-control, single centre study, carried out in a General Hospital in northern Italy. Sixty-three consecutive stroke patients were included, COVID-19-associated stroke was classified as cases and non COVID-19-associated stroke as controls.
A total of 19/63 (28.8%) had a COVID-19-associated stroke, 11 /63 (17.5%) were haemorrhagic and 52/63 (82.5%) ischaemic. COVID-19-associated strokes were more severe (p-value 0.019) and had a higher risk of severe disability and/or death (OR 3.79, CI 95%: 1.21-11.93, p-value 0.19). The COVID-19-associated stroke patients with onset during hospitalization for COVID-19 had a more severe stroke than patients with COVID-19 onset during hospitalization for stroke (p-value 0.019).
Although no relationship was observed between the stroke aetiology and COVID-19, intriguingly, COVID-associated stroke turned out to be more severe and disabling. Hopefully, further studies will provide more data and help in the management of this emerging population.
评估 COVID-19 是否可能是中风发生和/或恶化的并发因素，并提供第一波大流行期间 COVID-19 相关中风患者的数据以及同期 COVID-19 阴性中风患者的比较数据。
这是一项在意大利北部一家综合医院进行的回顾性、观察性、病例对照、单中心研究。共纳入 63 例连续中风患者，COVID-19 相关中风归类为病例，非 COVID-19 相关中风归类为对照。
共有 19/63 例（28.8%）为 COVID-19 相关中风，11/63 例（17.5%）为出血性，52/63 例（82.5%）为缺血性。COVID-19 相关中风更严重（p 值 0.019），严重残疾和/或死亡风险更高（OR 3.79，95%CI：1.21-11.93，p 值 0.19）。因 COVID-19 住院期间发病的 COVID-19 相关中风患者比因中风住院期间发病的 COVID-19 相关中风患者的中风更严重（p 值 0.019）。
尽管未观察到中风病因与 COVID-19 之间存在关系，但有趣的是，COVID 相关中风更严重且致残。希望进一步的研究将提供更多的数据并有助于管理这一新兴人群。
