Center for Cognitive Neurology, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Laboratory of Early Markers of Neurodegeneration, Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Medical Center, Tel Aviv, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Laboratory of Early Markers of Neurodegeneration, Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Medical Center, Tel Aviv, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
Clin Neurophysiol. 2022 Nov;143:14-20. doi: 10.1016/j.clinph.2022.08.011. Epub 2022 Aug 28.
To compare event-related oscillations in patients with dementia with Lewy bodies (DLB) who are carriers and non-carriers of glucocerebrosidase (GBA) mutations.
EEG was recorded during a visual oddball task in eight Ashkenazi Jewish DLB patients with the N370S mutation in theGBAgene (GBA-DLB) and eleven DLB non-carriers. The time-frequency power and inter-trial phase clustering were calculated from the Morlet wavelet convolution for the midline electrodes.
Task performance and cognitive assessments were comparable between groups. While the within-non-GBA-DLB group analysis revealed delta-band power synchronization relative to the baseline (p = 0.01, Cohen's d = 1.0), the within-GBA-DLB-group analysis detected no event-related changes in power. Both groups showed an increase relative to the baseline in the delta and theta bands inter-trial phase clustering (all p < 0.03, d > 1.3). The between-group analysis revealed that event-related power - but not clustering - was lower in GBA-DLB compared to non-carriers in the delta band at Fz and Cz (p = 0.04, d = -0.9).
GBA-DLB patients showed decreased delta-band power compared to non-carriers despite the similar cognitive performance, whereas inter-trial phase clustering was comparable in both groups.
Preserved inter-trial phase clustering possibly compensates for the impaired power by eliciting the appropriate functional configuration needed for stimulus processing and task performance.
比较携带和不携带葡萄糖脑苷脂酶（GBA）突变的路易体痴呆（DLB）患者与事件相关振荡的关系。
在视觉Oddball 任务中记录 8 名具有 GBA 基因 N370S 突变的阿什肯纳兹犹太裔 DLB 患者（GBA-DLB）和 11 名 DLB 非携带者的脑电图。从中线电极的 Morlet 小波卷积计算时频功率和试验间相位聚类。
两组的任务表现和认知评估相当。虽然非-GBA-DLB 组内分析显示相对于基线的 delta 波段功率同步（p = 0.01，Cohen's d = 1.0），但 GBA-DLB 组内分析未检测到与事件相关的功率变化。两组的 delta 和 theta 波段试验间相位聚类均相对于基线增加（均 p < 0.03，d > 1.3）。组间分析显示，与非携带者相比，GBA-DLB 患者在 delta 波段的额区和中央区的事件相关功率 - 而不是聚类 - 降低（p = 0.04，d = -0.9）。
尽管认知表现相似，但 GBA-DLB 患者的 delta 波段功率较非携带者降低，而试验间相位聚类在两组间相当。
试验间相位聚类的保留可能通过引发适当的功能配置来补偿受损的功率，从而为刺激处理和任务表现提供必要的功能配置。
