Ochikubo C G, Sunshine S E, Vreman H J, Ferguson J E, Stevenson D K
Dev Pharmacol Ther. 1987;10(2):118-24. doi: 10.1159/000457736.
Administration of nicardipine hydrochloride, a dihydropyridine calcium entry blocker, caused a 30% rise in the rate of bilirubin formation in neonatal rats. Plasma bilirubin concentrations also increased from 0.83 +/- 0.05 to 1.06 +/- 0.10 mg/100 ml (p less than 0.05). We conclude that maternal administration of nicardipine hydrochloride for tocolysis could affect bilirubin production in the neonate.
给予二氢吡啶类钙通道阻滞剂盐酸尼卡地平，可使新生大鼠胆红素生成率提高30%。血浆胆红素浓度也从0.83±0.05mg/100ml升高至1.06±0.10mg/100ml（P<0.05）。我们得出结论，母亲使用盐酸尼卡地平进行保胎治疗可能会影响新生儿胆红素的生成。
