Ochikubo C G, Sunshine S E, Vreman H J, Ferguson J E, Stevenson D K
Pediatr Pharmacol (New York). 1986;5(4):247-52.
The effect of ritodrine hydrochloride (RH) on bilirubin metabolism in newborn Wistar rats was studied. Wistar rat pups were given two 35-mg/kg injections of RH, and total bilirubin formation (TBF) was determined from the whole body excretion rate of carbon monoxide (VeCO). Early labeled bilirubin formation (ELB), plasma bilirubin levels, and hepatic heme oxygenase (HO) activity were also determined. We found significant increases in TBF, ELB, and HO in the RH-treated animals over the control animals. These increases, however, were small, considering the high doses of RH administered. Our findings suggest that at clinically administered doses, the potential for RH to exacerbate neonatal jaundice is minimal.
研究了盐酸利托君（RH）对新生Wistar大鼠胆红素代谢的影响。给Wistar大鼠幼崽注射两次35mg/kg的RH，通过一氧化碳的全身排泄率（VeCO）测定总胆红素生成量（TBF）。还测定了早期标记胆红素生成量（ELB）、血浆胆红素水平和肝血红素加氧酶（HO）活性。我们发现，与对照动物相比，接受RH治疗的动物的TBF、ELB和HO显著增加。然而，考虑到所给予的RH高剂量，这些增加幅度较小。我们的研究结果表明，在临床给药剂量下，RH加剧新生儿黄疸的可能性极小。
