Clozel M, Hascoet J M, Monin P, Vert P
Dev Pharmacol Ther. 1987;10(4):265-77. doi: 10.1159/000457753.
To assess the effects of intravenous tolazoline on hemodynamics and regional blood flow distribution, 12 anesthetized newborn piglets were studied. Six piglets received saline and served as controls, the other 6 received two bolus doses of tolazoline (1 and 2 mg/kg). Mean arterial blood pressure decreased from control levels of 69.4 +/- 5.6 to 54.6 +/- 7.0 and 47.0 +/- 5.6 mm Hg, respectively, after 1 and 2 mg/kg of tolazoline, and heart rate increased from 220 +/- 9 to 270 +/- 13 and 282 +/- 8 beats/min, respectively. Cardiac output and regional blood flows were measured 15 min after tolazoline by the radioactive microsphere technique. Cardiac index did not change significantly. There was a redistribution of cardiac output toward the coronary circulation, with an increase in coronary blood flow from a control value of 249.3 +/- 39.9 to 361.0 +/- 56.4 ml/min/100 g of tissue after 1 mg/kg of tolazoline. Bronchial blood flow was also significantly increased. After a dose of 2 but not 1 mg/kg, the renal blood flow was markedly decreased from 139.8 +/- 17.8 to 104.4 +/- 24.5 ml/min/100 g. The other regional blood flows were not significantly modified. We conclude that tolazoline is a potent coronary vasodilator during the neonatal period. In addition we speculate that the decrease in renal blood flow might play a role in the renal toxicity of tolazoline.
为评估静脉注射妥拉唑啉对血流动力学和局部血流分布的影响，对12只麻醉的新生仔猪进行了研究。6只仔猪接受生理盐水注射作为对照，另外6只接受两剂推注妥拉唑啉（1和2mg/kg）。注射1mg/kg和2mg/kg妥拉唑啉后，平均动脉血压分别从对照水平的69.4±5.6降至54.6±7.0和47.0±5.6mmHg，心率分别从220±9增至270±13和282±8次/分钟。在注射妥拉唑啉15分钟后，采用放射性微球技术测量心输出量和局部血流。心脏指数无显著变化。心输出量重新分布至冠状动脉循环，注射1mg/kg妥拉唑啉后，冠状动脉血流量从对照值249.3±39.9增至361.0±56.4ml/分钟/100g组织。支气管血流量也显著增加。注射2mg/kg而非1mg/kg后，肾血流量从139.8±17.8显著降至104.4±24.5ml/分钟/100g。其他局部血流无显著改变。我们得出结论，在新生儿期，妥拉唑啉是一种强效的冠状动脉血管扩张剂。此外，我们推测肾血流量的减少可能在妥拉唑啉的肾毒性中起作用。
