Vilaseca Isabel, Xavier Avilés-Jurado Francesc, Lehrer Eduardo, Valduvieco Izaskun, Baste Neus, Delia Ramírez Rosa, Miguel Costa José, Medrano-Martorell Santiago, Muxí África, Castillo Paola, Alós Llúcia, Bernal-Sprekelsen Manuel
Functional Unit of Head and Neck Tumors, Hospital Clínic, Barcelona, Spain; Otorhinolaryngology Department, Hospital Clínic, Barcelona, Spain; Surgery and Medical-Surgical Specialties Department, Faculty of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain; Translational Genomics and Target Therapies in Solid Tumors Group, Institut d́Investigacions Biomèdiques August Pi i Sunyer, IDIBAPS, Barcelona, Spain; Head Neck Clínic, Agència de Gestió d'Ajuts Universitaris i de Recerca, AGAUR 2017-SGR-01581, Barcelona, Spain.
Head Neck Clínic, Agència de Gestió d'Ajuts Universitaris i de Recerca, AGAUR 2017-SGR-01581, Barcelona, Spain; Head Neck Section, Otorhinolaryngology Department, Hospital Universitari Joan XXIII de Tarragona, Spain; Institut d'Investigació Sanitària Pere Virgili IISPV, Tarragona, Spain; Medicine and Surgery Department, Faculty of Medicine, Universitat Rovira i Virgili, Tarragona, Spain.
Oral Oncol. 2022 Nov;134:106088. doi: 10.1016/j.oraloncology.2022.106088. Epub 2022 Sep 7.
CO transoral laser microsurgery (CO-TOLMS) has pushed the indications of partial surgery of the larynx regardless the age of the patient.
To evaluate the complications and the oncologic and functional outcomes of CO-TOLMS in patients older and younger than 70 years.
Retrospective analysis of 1244 consecutive laryngeal carcinomas treated with CO-TOLMS. Complications, length of hospitalization, functional and survival outcomes were evaluated.
The mean age was 64.2 ± 11.1 years (20-96). Four hundred and sixteen patients were older than 70 years and 104 older than 80 years. The main location was the glottis (912), followed by the supraglottis (332). There were no differences in pT classification between the age groups. No differences were observed in voice outcomes. A higher rate of signs of aspiration at the glottic location was observed for those older than 70 years (2.1 % vs 5 %, p = 0.027). The need for definitive gastrostomy in supraglottic tumours was higher in those older than 70 years (0 % vs 6.5 %, p: 0.001). In the glottis, no differences in tracheostomy or gastrostomy rates were observed. Five-year overall survival was lower in the older than 70 years. No differences in disease-specific survival were observed in early stages for both locations, but a lower survival was observed in stage III glottic cancer for the older than 70 years.
CO-TOLMS is a valid treatment for laryngeal carcinomas in the elderly, with a reduced number of complications and good functional and oncologic outcomes.
二氧化碳经口激光显微手术(CO-TOLMS)拓展了喉部分切除术的适应证,不受患者年龄限制。
评估70岁及以上和70岁以下患者接受CO-TOLMS治疗后的并发症、肿瘤学及功能预后。
对1244例连续接受CO-TOLMS治疗的喉癌患者进行回顾性分析。评估并发症、住院时间、功能及生存预后。
平均年龄为64.2±11.1岁(20 - 96岁)。416例患者年龄大于70岁,104例年龄大于80岁。主要病变部位为声门(912例),其次为声门上区(332例)。各年龄组间pT分类无差异。语音预后无差异。70岁以上患者声门部位误吸征象发生率更高(2.1%对5%,p = 0.027)。70岁以上患者声门上区肿瘤行确定性胃造瘘术的需求更高(0%对6.5%,p: 0.001)。在声门区,气管切开术或胃造瘘术发生率无差异。70岁以上患者的5年总生存率较低。两个部位早期疾病特异性生存率无差异,但70岁以上患者声门癌III期生存率较低。
CO-TOLMS是老年喉癌的有效治疗方法,并发症较少,功能及肿瘤学预后良好。