放疗触发前药激活：精准化疗的新时代。
Radiotherapy-triggered prodrug activation: A new era in precise chemotherapy.
机构信息
Department of Gynecology and Obstetrics, XinHua Hospital Affiliated to Shanghai JiaoTong University School of Medicine, Shanghai 200092, China; DWI-Leibniz-Institute for Interactive Materials e.V., 52056 Aachen, Germany; Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, 52074 Aachen, Germany.
Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Medical Imaging, Shanghai 200032, China.
出版信息
Med. 2022 Sep 9;3(9):600-602. doi: 10.1016/j.medj.2022.08.004.
A major goal of cancer therapy is developing chemotherapy strategies that are accurate and efficient without being highly toxic. Recently, Bradley et al. and Liu et al. developed radioresponsive prodrugs, enabling site-directed, radiotherapy-triggered, and precise chemotherapy, which displays synergistic efficacy and avoids the serious side effects of conventional treatment approaches.
癌症治疗的一个主要目标是开发准确且高效而又不具有高毒性的化疗策略。最近，Bradley 等人和 Liu 等人开发了放射响应型前药，实现了靶向、放疗触发和精确的化疗，显示出协同疗效，并避免了传统治疗方法的严重副作用。
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