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SARS-CoV-2 变体的免疫逃逸范例及针对逃逸 VOC 的被颠覆单抗的重新定位策略。

The paradigm of immune escape by SARS-CoV-2 variants and strategies for repositioning subverted mAbs against escaped VOCs.

机构信息

Department of Physiology, Ajou University School of Medicine, Suwon 16499, Republic of Korea.

Department of Physiology, Ajou University School of Medicine, Suwon 16499, Republic of Korea; Department of Biomedical Science, Graduate School, Ajou University, Suwon 16499, Republic of Korea.

出版信息

Mol Ther. 2022 Oct 5;30(10):3101-3105. doi: 10.1016/j.ymthe.2022.08.020. Epub 2022 Sep 10.

DOI:10.1016/j.ymthe.2022.08.020
PMID:36087577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9462941/
Abstract

The perpetual emergence of SARS-CoV-2 variants is a serious issue that makes it difficult for the therapeutic antibodies and vaccines to end the COVID-19 pandemic. This article discusses the trend of increasing host fitness and immune escape by the virus and how to devise computational strategies for antibodies design and their affinity maturation against emerging SARS-CoV-2 variants.

摘要

不断出现的 SARS-CoV-2 变体是一个严重的问题，使得治疗性抗体和疫苗难以结束 COVID-19 大流行。本文讨论了病毒增加宿主适应性和免疫逃避的趋势，以及如何针对新兴的 SARS-CoV-2 变体设计抗体设计和亲和力成熟的计算策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8908/9551806/85c1dff9f593/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8908/9551806/bca05838a224/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8908/9551806/85c1dff9f593/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8908/9551806/bca05838a224/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8908/9551806/85c1dff9f593/gr2.jpg

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