生物分子组装对细胞天然因子的隔离：生理现象还是病理现象？
Sequestration of cellular native factors by biomolecular assemblies: Physiological or pathological?
作者信息
Hu Hong-Yu, Liu Ya-Jun
机构信息
State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, PR China.
State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
出版信息
Biochim Biophys Acta Mol Cell Res. 2022 Dec;1869(12):119360. doi: 10.1016/j.bbamcr.2022.119360. Epub 2022 Sep 7.
In addition to native-state structures, biomolecules often form condensed supramolecular assemblies or cellular membraneless organelles that are critical for cell life. These biomolecular assemblies, generally including liquid-like droplets (condensates) and amyloid-like aggregates, can sequester or recruit their interacting partners, so as to either modulate various cellular behaviors or even cause disorders. This review article summarizes recent advances in the sequestration of native factors by biomolecular assemblies and discusses their potential consequences on cellular function, homeostasis, and disease pathology.
除了天然状态的结构外，生物分子还常常形成凝聚的超分子聚集体或细胞无膜细胞器，这些对于细胞生命至关重要。这些生物分子聚集体，通常包括液滴状液滴（凝聚物）和淀粉样聚集体，能够隔离或招募其相互作用的伙伴，从而调节各种细胞行为，甚至引发疾病。这篇综述文章总结了生物分子聚集体隔离天然因子的最新进展，并讨论了它们对细胞功能、稳态和疾病病理学的潜在影响。
Zotero 插件