School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China; School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, China.
School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, China.
Carbohydr Polym. 2022 Nov 15;296:119947. doi: 10.1016/j.carbpol.2022.119947. Epub 2022 Aug 4.
Currently, microspheres with high adsorption capacity play a crucial role in dye adsorption and drug loading. In this study, 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)-oxidized cellulose nanofibrils (TOCN) could be used to form nanocellulose microspheres by the emulsion method. The prepared hydrangea-like nanocellulose microspheres presented a stable three-dimensional network porous structure and exhibited excellent adsorption properties. The TOCN microspheres had a high adsorption capacity for methylene blue (MB) and methyl orange (MO) with the optimal adsorption capacity of 412.1 mg g and 286.5 mg g under neutral conditions, respectively. The TOCN microspheres displayed excellent adsorption selectivity on MB/MO mixed dyes, which could be used to selectively adsorb MB. Besides, the encapsulation rate of the positively charged drug doxorubicin hydrochloride (DOX) was as high as 93 %, and the drug loading capacity was as high as 34.5 %. Overall, our prepared nanocellulose microspheres had great potential for application in dye adsorption and drug delivery systems.
目前，高吸附容量的微球在染料吸附和药物负载中起着至关重要的作用。在本研究中，2,2,6,6-四甲基哌啶-1-氧自由基（TEMPO）氧化纤维素纳米纤维（TOCN）可通过乳液法形成纳米纤维素微球。所制备的绣球花状纳米纤维素微球呈现出稳定的三维网络多孔结构，并表现出优异的吸附性能。在中性条件下，TOCN 微球对亚甲基蓝（MB）和甲基橙（MO）具有高吸附容量，最大吸附容量分别为 412.1mg/g 和 286.5mg/g。TOCN 微球对 MB/ MO 混合染料表现出优异的吸附选择性，可用于选择性吸附 MB。此外，带正电荷的盐酸阿霉素（DOX）的包封率高达 93%，载药量高达 34.5%。总的来说，我们制备的纳米纤维素微球在染料吸附和药物传递系统中有很大的应用潜力。
