Department of Clinical Microbiology, CMC Vellore, Tamil Nadu, India.
Department of Clinical Microbiology, CMC Vellore, Tamil Nadu, India.
Indian J Med Microbiol. 2022 Oct-Dec;40(4):582-584. doi: 10.1016/j.ijmmb.2022.08.010. Epub 2022 Sep 8.
Nocardiosis is a clinical and diagnostic challenge. This was a retrospective study carried out on cases of pulmonary nocardiosis presenting over 15 years. Clinical data was retrieved using the electronic patient records. Vitek MS 3.2 (MALDI TOF MS) was carried out on 22 isolates and sequencing on another 9 isolates. Of 71 patients presenting with pulmonary nocardiosis, 58 (81.6%) were on immunosuppressant therapy, 26 (46%) had a previous lung pathology, 11 (8%) were HIV associated. Disseminated disease was seen in 6 (8.4%). There were 8 (11.26%) deaths in this cohort of patients. Of 31/71 identified to species, the most common were Nocardia cyriacigeorgica (n = 11) followed by Nocardia farcinica (n = 9).
奴卡菌病是一种临床和诊断上的挑战。这是一项对超过 15 年期间出现的肺部奴卡菌病病例进行的回顾性研究。使用电子病历检索临床数据。对 22 株分离株进行了 Vitek MS 3.2（MALDI-TOF MS）检测，对另外 9 株分离株进行了测序。在 71 例患有肺部奴卡菌病的患者中，58 例（81.6%）正在接受免疫抑制剂治疗，26 例（46%）有既往肺部病理学，11 例（8%）与 HIV 相关。6 例（8.4%）患者出现播散性疾病。该患者队列中有 8 例（11.26%）死亡。在 71 例鉴定到种的患者中，最常见的是触须奴卡菌（n=11），其次是星形奴卡菌（n=9）。
