Hunan Key Laboratory of Biomedical Nanometer and Device, Hunan University of Technology, Zhuzhou 412007, PR China.
Hunan Key Laboratory of Biomedical Nanometer and Device, Hunan University of Technology, Zhuzhou 412007, PR China.
J Colloid Interface Sci. 2023 Jan;629(Pt A):467-477. doi: 10.1016/j.jcis.2022.08.146. Epub 2022 Aug 27.
Healthy articular cartilage can achieve high load-bearing capacity and the most effective lubricated surface. Inspired by the articular cartilage, a lipid-lubricated hydrogel with excellent mechanical strength and remarkable lubrication was designed and synthesized. The lipid-lubricated hydrogel could contribute to high strength and stiffness (compressive strength of 5.8 MPa and compressive modulus of 4.7 MPa at 50% strain), and it could recover more than 98% of original mechanical properties in a short time after loading-unloading. In addition, the friction coefficient of lipid-lubricated hydrogel is low as 0.026, 5.3 times smaller than hydrogel without adding the liposomes. Overall, the hydrogel we studied holds the potential as a load-bearing soft tissue substitute for articular cartilage.
健康的关节软骨具有较高的承载能力和最有效的润滑表面。受关节软骨的启发，设计并合成了一种具有优异机械强度和显著润滑性能的脂质润滑水凝胶。脂质润滑水凝胶具有高强度和高刚性（在 50%应变下压缩强度为 5.8 MPa，压缩模量为 4.7 MPa），在加载-卸载后能在短时间内恢复超过 98%的原始机械性能。此外，脂质润滑水凝胶的摩擦系数较低，仅为 0.026，比未添加脂质体的水凝胶小 5.3 倍。总的来说，我们研究的水凝胶具有作为关节软骨的承重软组织替代品的潜力。
