Filanovskaia L I, Blinov M N, Togo A V
Eksp Onkol. 1987;9(3):39-43.
The degree of action of purine nucleosides (adenosine, deoxyadenosine (d-ado) and deoxyguanosine (d-gua] on peripheral blood leukocytes in leukemias has been shown to change, as estimated by their inhibition of the protein biosynthesis. The inhibitory effect of purines on lymphocytes of the CLL patients and on myeloid cells of patients is decreased as compared to the normal cells. On the contrary, blast cells in T-ALL and AML exhibit the increased sensitivity to d-gua and d-ado. The cytotoxicity of d-ado, as compared to that of other nucleosides, is markedly higher against both the normal and leukemic lymphoid and myeloid cells. The relationship between the differences in purine nucleoside action on the normal and leukemic cells and the peculiar features of the nucleotide metabolism in these cells is discussed.
嘌呤核苷（腺苷、脱氧腺苷（d-ado）和脱氧鸟苷（d-gua））对白血病患者外周血白细胞的作用程度已被证明会发生变化，这是通过它们对蛋白质生物合成的抑制作用来估计的。与正常细胞相比，嘌呤对慢性淋巴细胞白血病（CLL）患者淋巴细胞和患者髓细胞的抑制作用降低。相反，T细胞急性淋巴细胞白血病（T-ALL）和急性髓细胞白血病（AML）中的原始细胞对d-gua和d-ado表现出更高的敏感性。与其他核苷相比，d-ado对正常和白血病淋巴及髓细胞的细胞毒性明显更高。本文讨论了嘌呤核苷对正常细胞和白血病细胞作用差异与这些细胞中核苷酸代谢特性之间的关系。
