Sperling O, Brosh S, Boer P, Kupfer B, Benjamin B, Weinberger A, Pinkhas J
Biomedicine. 1979 Feb;31(1):20-3.
Among normal peripheral blood leukocytes, lymphocytes were found to contain most of the de novo purine synthesizing capacity. The rate of purine synthesis de novo was accelerated in leukocytes from patients with acute and chronic myelocytic leukemias, chronic monocytic leukemia, myelofibrosis and plasma cell leukemia, but was normal in most patients with chronic lymphocytic leukemia. The rate of de novo purine synthesis exhibited positive correlation with the percentage of immature cells in the leukocyte population. The metabolic availability of phosphoribosylpyrophosphate (PRPP) exhibited positive correlation with the state of de novo purine synthesis. These finding suggest that the accelerated rate of de novo purine synthesis and the increased metabolic availability of PRPP are characteristic properties of the immature leukemic granulocyte.
在正常外周血白细胞中，发现淋巴细胞含有大部分从头合成嘌呤的能力。急性和慢性粒细胞白血病、慢性单核细胞白血病、骨髓纤维化和浆细胞白血病患者的白细胞中嘌呤从头合成速率加快，但大多数慢性淋巴细胞白血病患者的该速率正常。嘌呤从头合成速率与白细胞群体中未成熟细胞的百分比呈正相关。磷酸核糖焦磷酸（PRPP）的代谢可用性与嘌呤从头合成状态呈正相关。这些发现表明，嘌呤从头合成速率加快和PRPP代谢可用性增加是未成熟白血病粒细胞的特征性特性。
