Guanrei Y, Songliang Q
Endoscopy. 1987 May;19(3):91-5. doi: 10.1055/s-2007-1018250.
Endoscopic surveys were carried out of the people in high-risk and low-risk areas of esophageal cancer in Henan Province, China. Chronic esophagitis was observed with endoscopy in 70.67% of the inhabitants in the high-risk area and in 63.67% of the individuals in the low-risk area. The prevalence rate of chronic esophagitis diagnosed with histological examination was 78.28% and 71.33% in the two groups, respectively. Basal-cell hyperplasia and dysplasia were present in 74% and 38.28% of the populations, respectively, in the high-risk area, and in 48% and 4.78% of the inhabitants in the low-risk area. A correlation between the incidence of dysplasia and the severity of esophagitis was found in two groups. One-hundred-and-eighty-six cases of chronic esophagitis in high-risk areas were followed-up with endoscopy from 30 to 78 months. Of the 186 cases, in 62 accompanied by dysplasia 21 (33.87%) developed early stage esophageal carcinoma; and in 124 cases with esophagitis alone or simple hyperplasia cancer was found in 5 (4.03%). We suggest that chronic esophagitis is the commonest disease of the esophagus due to mechanical irritation, thermal injury and vitamin deficiencies, while the inflammatory injury may increase the sensitivity of the esophageal mucosa to carcinogens. It might be concluded that esophagitis with dysplasia was likely to develop into esophageal carcinoma and that treatment of this disease would be important to decrease the incidence rate of esophageal cancer.
对中国河南省食管癌高风险和低风险地区的人群进行了内镜检查。高风险地区70.67%的居民和低风险地区63.67%的个体经内镜检查发现患有慢性食管炎。两组经组织学检查确诊的慢性食管炎患病率分别为78.28%和71.33%。高风险地区分别有74%和38.28%的人群存在基底细胞增生和发育异常，低风险地区分别有48%和4.78%的居民存在基底细胞增生和发育异常。两组均发现发育异常的发生率与食管炎的严重程度之间存在相关性。对高风险地区的186例慢性食管炎患者进行了30至78个月的内镜随访。在这186例患者中，62例伴有发育异常，其中21例（33.87%）发展为早期食管癌；124例仅患有食管炎或单纯增生，其中5例（4.03%）发现患有癌症。我们认为，慢性食管炎是由于机械刺激、热损伤和维生素缺乏引起的最常见的食管疾病，而炎症损伤可能会增加食管黏膜对致癌物的敏感性。可以得出结论，伴有发育异常的食管炎可能会发展为食管癌，对这种疾病的治疗对于降低食管癌的发病率很重要。
