Department of Veterinary Pathology, Tokyo, Japan.
Department of Veterinary Pathology, Tokyo, Japan.
J Comp Pathol. 2022 Sep;197:19-22. doi: 10.1016/j.jcpa.2022.06.005. Epub 2022 Aug 10.
A 12-year-old spayed Shiba dog with a nasal neuroendocrine carcinoma and multiple hepatic nodules was necropsied. Histologically, proliferated blast cells with a monolayer or multilayered structure were observed in the kidney. This blast cell proliferation extended from Bowman's capsule epithelium to the proximal tubule in approximately 3% of nephrons. Immunohistochemistry revealed that blast cells were positive for vimentin, Wilm's tumour protein 1 (WT1), paired box 2 (PAX2) and CD10, but negative for cytokeratin (CK) AE1/AE3, CK19, CAM5.2, synaptophysin and chromogranin A. On the basis of these findings, adenomatous hyperplasia of Bowman's capsule epithelium was diagnosed. Multiple yellowish‒white nodules (1-3 cm) were found in the liver and diagnosed as neuroendocrine carcinoma with metastases to the lungs, adrenal glands and pancreaticoduodenal lymph nodes.
一只 12 岁已去势的雌性柴犬因鼻腔神经内分泌癌和多个肝脏结节而接受剖检。组织学上，在肾脏中观察到增殖的呈单层或多层结构的成神经细胞瘤。这种成神经细胞瘤增殖从鲍曼氏囊上皮延伸到大约 3%的肾单位的近端小管。免疫组织化学显示，成神经细胞瘤对波形蛋白、Wilms 瘤蛋白 1（WT1）、配对盒 2（PAX2）和 CD10 呈阳性，但对细胞角蛋白（CK）AE1/AE3、CK19、CAM5.2、突触素和嗜铬粒蛋白 A 呈阴性。基于这些发现，诊断为鲍曼氏囊上皮的腺瘤性增生。肝脏中发现多个黄白色结节（1-3 厘米），诊断为神经内分泌癌，并转移至肺部、肾上腺和胰十二指肠淋巴结。
