School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia; Centre for Bioinnovation, School of Science, Technology and Engineering, University of the Sunshine Coast, Sippy Downs, Queensland, Australia.
School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia.
J Comp Pathol. 2022 Sep;197:44-52. doi: 10.1016/j.jcpa.2022.07.005. Epub 2022 Aug 31.
The objective of this study was to evaluate critically the nature and prevalence of histological pulmonary lesions in dogs and cats that had died or were euthanized because of tick paralysis. A retrospective and prospective case study of 11 cats and 23 dogs was carried out. Retrospective cases were gathered from the Veterinary Laboratory Services database at The University of Queensland (UQ). Prospective cases were provided by Veterinary Specialist Services and UQ VETs Small Animal Hospital. Lung and other tissue samples were collected for histopathological analysis. All tick intoxicated animals demonstrated evidence of pulmonary parenchymal changes: alveolar oedema, interstitial and alveolar congestion and alveolar fibrin exudation. Eleven of 23 (48%) dogs exhibited mild to severe bronchopneumonia. A lower rate (18%) of bronchopneumonia was found in cats, with one case of aspiration pneumonia. A novel pulmonary histological grading scheme was developed to evaluate the correlation between clinical presentation and histopathological changes. Novel extrapulmonary lesions in cats included hepatic necrosis and acute renal tubular necrosis attributed to hypoxia. We concluded that both dogs and cats with high clinical grade tick paralysis are extremely likely to have pulmonary pathology. High-protein oedema and fibrin exudation are predicted to be present in most cases of canine and feline tick paralysis.
本研究旨在批判性地评估因蜱瘫痪而死亡或安乐死的犬猫的肺部组织病理学病变的性质和流行情况。对 11 只猫和 23 只狗进行了回顾性和前瞻性病例研究。回顾性病例来自昆士兰大学（UQ）兽医实验室服务数据库。前瞻性病例由兽医专科服务和 UQ VETS 小动物医院提供。采集肺和其他组织样本进行组织病理学分析。所有蜱中毒动物均表现出肺实质变化的证据：肺泡水肿、间质和肺泡充血以及肺泡纤维蛋白渗出。23 只狗中有 11 只（48%）表现出轻度至重度支气管肺炎。猫的支气管肺炎发生率较低（18%），其中 1 例为吸入性肺炎。制定了一种新的肺部组织学分级方案，以评估临床表型与组织病理学变化之间的相关性。猫的新型肺外病变包括肝坏死和急性肾小管坏死，归因于缺氧。我们得出结论，临床分级高的蜱瘫痪犬猫极有可能存在肺部病理学变化。大多数犬猫的蜱瘫痪病例都存在高蛋白性水肿和纤维蛋白渗出。
