Brooks Lucy J, Simpson Ragdale Holly, Hill Ciaran Scott, Clements Melanie, Parrinello Simona
Samantha Dickson Brain Cancer Unit, Department of Cancer Biology, University College London Cancer Institute, London, UK.
Samantha Dickson Brain Cancer Unit, Department of Cancer Biology, University College London Cancer Institute, London, UK.
Trends Neurosci. 2022 Nov;45(11):865-876. doi: 10.1016/j.tins.2022.08.006. Epub 2022 Sep 9.
Glioblastoma is the most common and aggressive primary brain cancer in adults and is almost universally fatal due to its stark therapeutic resistance. During the past decade, although survival has not substantially improved, major advances have been made in our understanding of the underlying biology. It has become clear that these devastating tumors recapitulate features of neurodevelopmental hierarchies which are influenced by the microenvironment. Emerging evidence also highlights a prominent role for injury responses in steering cellular phenotypes and contributing to tumor heterogeneity. This review highlights how the interplay between injury and neurodevelopmental programs impacts on tumor growth, invasion, and treatment resistance, and discusses potential therapeutic considerations in view of these findings.
胶质母细胞瘤是成人中最常见且侵袭性最强的原发性脑癌，由于其极强的治疗抗性，几乎无一例外都会导致死亡。在过去十年间，尽管生存率并未显著提高，但我们对其潜在生物学特性的理解取得了重大进展。已经明确的是，这些毁灭性肿瘤重现了受微环境影响的神经发育层级特征。新出现的证据还凸显了损伤反应在引导细胞表型和导致肿瘤异质性方面的重要作用。本综述强调了损伤与神经发育程序之间的相互作用如何影响肿瘤生长、侵袭和治疗抗性，并鉴于这些发现讨论了潜在的治疗考量。
