Hic 与 Runx：T 细胞组织归巢的新见解。
Hic et Runx: new insights into T cell tissue residency.
机构信息
Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USA.
Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USA.
出版信息
Trends Immunol. 2022 Oct;43(10):780-781. doi: 10.1016/j.it.2022.08.006. Epub 2022 Sep 8.
Abstract
Tissue-resident memory T cells (Trm), which typically do not enter the blood or lymphatic circulation at steady-state, are considered crucial for controlling pathogen entry at skin and mucosal barriers. Two recent studies (Fonseca et al. and Crowl et al.) shed light on the mechanisms of Trm cell differentiation.
摘要
组织驻留记忆 T 细胞（Trm）在稳态时通常不会进入血液或淋巴循环，被认为对控制皮肤和黏膜屏障处病原体的入侵至关重要。最近的两项研究（Fonseca 等人和 Crowl 等人）揭示了 Trm 细胞分化的机制。
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本文引用的文献
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Nat Immunol. 2022 Aug;23(8):1236-1245. doi: 10.1038/s41590-022-01273-4. Epub 2022 Jul 26.
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Tissue-resident memory CD8 T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments.组织驻留记忆 CD8 T 细胞具有独特的转录、表观遗传和功能适应不同的组织环境。
Nat Immunol. 2022 Jul;23(7):1121-1131. doi: 10.1038/s41590-022-01229-8. Epub 2022 Jun 27.
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Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity.离散的组织微环境指导驻留记忆 T 细胞功能和可塑性的多样性。
Nat Immunol. 2021 Sep;22(9):1140-1151. doi: 10.1038/s41590-021-01004-1. Epub 2021 Aug 23.
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Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8 Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β.通过嘌呤能受体 P2RX7 感应 ATP 促进 CD8 Trm 细胞的生成，增强其对细胞因子 TGF-β 的敏感性。
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