University of Minnesota, Center for Immunology, 2101 6th St SE, 2-260 WMBB, Minneapolis, MN 55455, United States.
University of Minnesota, Center for Immunology, 2101 6th St SE, 2-260 WMBB, Minneapolis, MN 55455, United States.
Curr Opin Immunol. 2020 Apr;63:35-42. doi: 10.1016/j.coi.2020.01.001. Epub 2020 Feb 1.
Advances in the field of T cell memory, including the discovery of tissue residency, continue to add to the list of defined T cell subsets. Here, we briefly review the role of resident memory T cells (T) in protective immunity, and propose that they exhibit developmental and migrational plasticity. We discuss T cell classification, the concept of cell type versus 'subset', and the difficulty of inferring developmental relationships between cells occupying malleable differentiation states. We propose that popular subsetting strategies do not perfectly define boundaries of developmental potential. We integrate T into a 'terrace' model that classifies memory T cells along a continuous axis of decreasing developmental potential. This model also segregates cells on the basis of migration properties, although different migration properties are viewed as parallel differentiation states that may be permissive to change.
在 T 细胞记忆领域的进展中，包括组织驻留的发现，不断增加已定义的 T 细胞亚群列表。在这里，我们简要回顾了驻留记忆 T 细胞（T）在保护性免疫中的作用，并提出它们表现出发育和迁移的可塑性。我们讨论了 T 细胞分类、细胞类型与“亚群”的概念，以及推断占据可塑分化状态的细胞之间发育关系的困难。我们提出，流行的亚群划分策略并不能完美地定义发育潜力的边界。我们将 T 整合到一个“梯田”模型中，该模型沿着发育潜力逐渐降低的连续轴对记忆 T 细胞进行分类。该模型还基于迁移特性对细胞进行分类，尽管不同的迁移特性被视为可能允许改变的平行分化状态。
