Department of Gynecology, Sapporo Medical University, 291, West 16, South 1, Chuo-Ku, Sapporo, Hokkaido, 060-8543, Japan.
Department of Obstetrics and Gynecology, Steel Memorial Muroran Hospital, Hokkaido, 050-0076, Japan.
Int J Clin Oncol. 2022 Nov;27(11):1742-1749. doi: 10.1007/s10147-022-02238-1. Epub 2022 Sep 11.
Human papillomavirus (HPV) testing using self-collected vaginal samples and urine samples is convenient and effective for improving the screening rate. But, to serve as an alternative cervical cancer screening technique, such tests must offer sensitivity equivalent to the HPV testing of physician-collected cervical samples. To examine the effectiveness of HPV testing using self-collected samples and urine samples, we compared the results of HPV testing using these samples with those of HPV testing using physician-collected samples and cytological examinations.
The study population included 300 women (age: 20-50 years) with abnormal cervical cytology. The results of HPV testing using self-collected samples and urine samples and physician-collected samples and cervical cytology were compared.
For all HPV types, the κ-value was 0.773 for physician- and self-collected samples and 0.575 for physician-collected and urine samples. The κ-value for HPV type 16-positive samples was 0.988 for physician- and self-collected samples and 0.896 for physician-collected and urine samples. The κ-value for HPV type 18-positive samples was 0.856 for physician- and self-collected samples and 0.831 for physician-collected and urine samples. For other HPV types, the value was 0.809 for physician- and self-collected samples and 0.617 for physician-collected and urine samples.
The obtained results were consistent between physician- and self-collected samples as well as between physician-collected and urine samples. Considering that the agreement rate was particularly high for the high-risk HPV types 16 and 18, HPV testing using physician-collected samples, self-collected samples, and urine samples was equally effective for the types with high carcinogenicity.
人乳头瘤病毒（HPV）检测采用自采阴道样本和尿液样本，方便有效，可提高筛查率。但作为宫颈癌筛查技术的替代方法，此类检测必须具有与医生采集的宫颈样本 HPV 检测相当的敏感性。为了评估使用自采样本和尿液样本进行 HPV 检测的效果，我们比较了这些样本与医生采集样本和细胞学检查的 HPV 检测结果。
研究人群包括 300 名（年龄 20-50 岁）宫颈细胞学异常的女性。比较了自采样本和尿液样本与医生采集样本和宫颈细胞学检查的 HPV 检测结果。
所有 HPV 类型中，医生采集样本与自采样本的κ 值为 0.773，医生采集样本与尿液样本的κ 值为 0.575。HPV 16 阳性样本的κ 值为医生采集样本与自采样本的 0.988，为医生采集样本与尿液样本的 0.896。HPV 18 阳性样本的κ 值为医生采集样本与自采样本的 0.856，为医生采集样本与尿液样本的 0.831。其他 HPV 类型的κ 值为医生采集样本与自采样本的 0.809，为医生采集样本与尿液样本的 0.617。
医生采集样本与自采样本以及医生采集样本与尿液样本的检测结果具有一致性。鉴于高危型 HPV 16 和 18 的一致性特别高，医生采集样本、自采样本和尿液样本的 HPV 检测对高致癌性类型同样有效。
