Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Korea.
Center for Synapse Diversity and Specificity, DGIST, Daegu, Korea.
Bioessays. 2022 Nov;44(11):e2200134. doi: 10.1002/bies.202200134. Epub 2022 Sep 11.
Bidirectional trans-synaptic signaling is essential for the formation, maturation, and plasticity of synaptic connections. Synaptic cell adhesion molecules (CAMs) are prime drivers in shaping the identities of trans-synaptic signaling pathways. A series of recent studies provide evidence that diverse presynaptic cell adhesion proteins dictate the regulation of specific synaptic properties in postsynaptic neurons. Focusing on mammalian synaptic CAMs, this article outlines several exemplary cases supporting this notion and highlights how these trans-synaptic signaling pathways collectively contribute to the specificity and diversity of neural circuit architecture.
双向突触传递信号对于突触连接的形成、成熟和可塑性至关重要。突触细胞粘附分子（CAMs）是塑造突触传递信号通路特性的主要驱动力。一系列最近的研究提供了证据，表明不同的突触前细胞粘附蛋白决定了突触后神经元特定突触特性的调节。本文聚焦于哺乳动物突触 CAMs，概述了支持这一观点的几个典型案例，并强调了这些突触传递信号通路如何共同促进神经回路结构的特异性和多样性。
