低分子肝素单独或联合阿司匹林治疗胎儿生长受限的比较。
Comparison of Low Molecular Weight Heparin Used alone or Combined with Aspirin in the Treatment of Fetal Growth Restriction.
机构信息
Department of Obstetrics, Xinchang people's Hospital, Shaoxing, China.
Department of Gynaecology, Xinchang people's Hospital, Shaoxing, China.
出版信息
J Coll Physicians Surg Pak. 2022 Sep;32(9):1228-1229. doi: 10.29271/jcpsp.2022.09.1228.
The objective of the study was to compare the efficacy of low-molecular weight heparin (LMWH) alone and use in the combination with aspirin in the treatment of fetal growth restriction (FGR) patients. Ninety-six FGR patients were divided into the LMWH group (n=48) and the combined group (n=48), according to the different treatments. This research showed after treatment, values of PI, RI and S/D, serum IL-6 and TNF-α in the combined group were lower than those in the LMWH group (all p <0.001). The frequency of pregnancy complications and adverse neonatal outcomes in the combined group were 2 (4.2%) lower than the LMWH group (p=0.045, 0.025). Combination of LMWH with aspirin in FGR patients effectively reduced levels of IL-6 and TNF-α within the mother, improved fetal developmental parameters, and reduced the frequency of pregnancy complications and adverse neonatal outcomes compared with LMWH treatment alone. Key Words: Fetal growth restriction (FGR), Low-molecular weight heparin (LMWH), Aspirin, Pregnancy, Newborn.
本研究旨在比较单独使用低分子肝素（LMWH）和联合使用阿司匹林治疗胎儿生长受限（FGR）患者的疗效。96 例 FGR 患者根据不同的治疗方法分为 LMWH 组（n=48）和联合组（n=48）。研究表明，治疗后联合组的 PI、RI 和 S/D 值、血清 IL-6 和 TNF-α均低于 LMWH 组（均 P<0.001）。联合组的妊娠并发症和不良新生儿结局的发生率均低于 LMWH 组（分别为 4.2%和 2 例比 11.1%，P=0.045 和 0.025）。与单独使用 LMWH 相比，联合使用 LMWH 和阿司匹林可有效降低母体中 IL-6 和 TNF-α 的水平，改善胎儿发育参数，并降低妊娠并发症和不良新生儿结局的发生率。关键词：胎儿生长受限（FGR）、低分子肝素（LMWH）、阿司匹林、妊娠、新生儿。
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