Department of Obstetrics, Huai'an Maternity and Child Care Hospital, Huaian 223001, Jiangsu, China.
J Healthc Eng. 2021 Oct 16;2021:9697962. doi: 10.1155/2021/9697962. eCollection 2021.
This study explored the clinical application value of image denoising algorithm combined with Doppler ultrasound imaging in evaluation of aspirin combined with low-molecular-weight heparin (LMWH) on fetal growth restriction (FGR).
A two-stage image denoising by principal component analysis (PCA) with local pixel grouping (LPG-PCA) denoising algorithm was constructed in this study. Eighty FGR pregnant women were included in the study, and they were rolled into an experimental group (aspirin enteric-coated tablets + LMWH calcium injection) and a control group (LMWH calcium injection) according to the different treatment plans, with 40 cases in each group. All patients were performed with Doppler ultrasound imaging. The blood flow parameters (BFPs) were recorded and compared before and after the treatment in two groups, including power index (PI), resistance index (RI), high systolic blood flow velocity (S), high diastolic blood flow velocity (D), S/D value, and peak systolic velocity (PSV). In addition, the middle cerebral artery (MCA) BFPs, cerebral placental rate (CPR), amniotic fluid index (AFI) and perinatal outcome (PO) of the two groups were compared.
The total effective rate of treatment in group A (87.5%) was greatly higher than that in group B (62.5%), showing statistical difference ( < 0.05). The PI (0.72 ± 0.19), RI (0.57 ± 0.17), and S/D values (2.26 ± 0.43) in group A were dramatically lower than those in group B, which were 0.92 ± 0.21, 0.75 ± 0.14, and 2.64 ± 0.45, respectively ( < 0.05), and the AFI was higher (13.71 ± 2.2 cm vs 11.38 ± 2.16 cm) ( < 0.05). The Apgar score (9.17 ± 0.26), weight (3.57 ± 1.08), and gestational age (38.85 ± 2.50) of group A were all higher in contrast to those of group B, which were 7.33 ± 0.25, 2.61 ± 1.13, and 36.18 ± 2.25, respectively ( < 0.05). In addition, the fetal double parietal diameter (2.4 ± 0.9 mm), femur diameter (2.2 ± 0.6 mm), head circumference (1.2 ± 0.4 mm), abdominal circumference (1.3 ± 0.7 mm), and uterine height (0.8 ± 0.3 mm) in group A were obviously superior to those in group B, which were 1.8 ± 0.4 mm, 1.7 ± 0.5 mm, 0.8 ± 0.2 mm, 0.9 ± 0.4 mm, and 0.4 ± 0.6 mm, respectively, showing statistically observable differences ( < 0.05).
Doppler ultrasound based on image denoising algorithm can accurately evaluate the effect of aspirin combined with LMWH on the improvement of FGR and showed good application value.
探讨基于图像去噪算法的多普勒超声成像在评估阿司匹林联合低分子肝素（LMWH）对胎儿生长受限（FGR）的临床应用价值。
本研究构建了基于主成分分析（PCA）和局部像素分组（LPG-PCA）的两阶段图像去噪算法。将 80 例 FGR 孕妇纳入研究，根据不同的治疗方案分为实验组（阿司匹林肠溶片+LMWH 钙注射液）和对照组（LMWH 钙注射液），每组 40 例。所有患者均进行多普勒超声成像。记录并比较两组患者治疗前后的血流参数（BFPs），包括搏动指数（PI）、阻力指数（RI）、收缩期血流速度高（S）、舒张期血流速度高（D）、S/D 值和收缩期峰值速度（PSV）。此外，比较两组患者的大脑中动脉（MCA）BFPs、脑胎盘率（CPR）、羊水指数（AFI）和围生期结局（PO）。
A 组（87.5%）的总有效率明显高于 B 组（62.5%），差异具有统计学意义（<0.05）。A 组的 PI（0.72±0.19）、RI（0.57±0.17）和 S/D 值（2.26±0.43）明显低于 B 组（0.92±0.21、0.75±0.14 和 2.64±0.45），差异具有统计学意义（<0.05），且 AFI 更高（13.71±2.2 cm 比 11.38±2.16 cm）（<0.05）。A 组的 Apgar 评分（9.17±0.26）、体重（3.57±1.08）和胎龄（38.85±2.50）均明显高于 B 组（7.33±0.25、2.61±1.13 和 36.18±2.25），差异具有统计学意义（<0.05）。此外，A 组的胎儿双顶径（2.4±0.9 mm）、股骨长（2.2±0.6 mm）、头围（1.2±0.4 mm）、腹围（1.3±0.7 mm）和宫高（0.8±0.3 mm）均明显优于 B 组（1.8±0.4 mm、1.7±0.5 mm、0.8±0.2 mm、0.9±0.4 mm 和 0.4±0.6 mm），差异具有统计学意义（<0.05）。
基于图像去噪算法的多普勒超声能准确评估阿司匹林联合 LMWH 改善 FGR 的效果，具有良好的应用价值。
